Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD

Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 255(2023) vom: 01. Okt., Seite 109750
1. Verfasser: Gupta, Prachi Mehrotra (VerfasserIn)
Weitere Verfasser: Balle, Christina, Tharp, Gregory K, Nelson, Sydney A, Gasper, Melanie A, Brown, Bryan, Alisoltani, Arghavan, Onono, Maricianah, Palanee-Phillips, Thesla, Nair, Gonsagrie, Ayele, Hosseana, Noel-Romas, Laura, Passmore, Jo-Ann S, Burgener, Adam D, Heffron, Renee, Jaspan, Heather B, Bosinger, Steven E
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Randomized Controlled Trial Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural Contraception Female genital tract Mucosa Randomized clinical trial Reproductive health Transcriptome mehr... Copper 789U1901C5 Levonorgestrel 5W7SIA7YZW Contraceptive Agents
Beschreibung
Zusammenfassung:Copyright © 2023. Published by Elsevier Inc.
Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not been evaluated in a randomized clinical trial setting. Here, we evaluated the effect of three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and a copper intrauterine device (Cu-IUD), on the endocervical host transcriptome in 188 women from the Evidence for Contraceptive Options and HIV Outcomes Trial (ECHO) trial. Cu-IUD usage showed the most extensive transcriptomic changes, and was associated with inflammatory and anti-viral host responses. DMPA-IM usage was enriched for pathways associated with T cell responses. LNG implant had the mildest effect on endocervical gene expression, and was associated with growth factor signaling. These data provide a mechanistic basis for the diverse influence that varying contraceptives have on the FGT
Beschreibung:Date Completed 16.11.2023
Date Revised 10.04.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109750