Incorporating a β-hairpin sequence motif to increase intracellular stability of a peptide-based PROTAC

Proteolysis targeting chimeras (PROTACs) have emerged as a new class of therapeutics that utilize the ubiquitin-proteasome system (UPS) to facilitate proteasomal degradation of "undruggable" targets. Peptide-based PROTACs contain three essential components: a binding motif for the target p...

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Publié dans:	Biochemical engineering journal. - 1998. - 199(2023) vom: 21. Okt.
Auteur principal:	Hymel, Hannah C (Auteur)
Autres auteurs:	Anderson, Jeffery C, Liu, Dong, Gauthier, Ted J, Melvin, Adam T
Format:	Article en ligne
Langue:	English
Publié:	2023
Accès à la collection:	Biochemical engineering journal
Sujets:	Journal Article PROTAC Peptide-based therapeutics β-hairpin