Incorporating a β-hairpin sequence motif to increase intracellular stability of a peptide-based PROTAC
Proteolysis targeting chimeras (PROTACs) have emerged as a new class of therapeutics that utilize the ubiquitin-proteasome system (UPS) to facilitate proteasomal degradation of "undruggable" targets. Peptide-based PROTACs contain three essential components: a binding motif for the target p...
| Veröffentlicht in: | Biochemical engineering journal. - 1998. - 199(2023) vom: 21. Okt. |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2023
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| Zugriff auf das übergeordnete Werk: | Biochemical engineering journal |
| Schlagworte: | Journal Article PROTAC Peptide-based therapeutics β-hairpin |
| Online verfügbar |
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