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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202305868
|2 doi
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|a pubmed24n1588.xml
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|a eng
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| 100 |
1 |
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|a Zhang, Zefu
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Treatment of Ruptured Wide-Necked Aneurysms using a Microcatheter Injectable Biomaterial
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|c 2023
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 17.11.2023
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|a Date Revised 02.11.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Ruptured wide-neck aneurysms (WNAs), especially in a setting of coagulopathy, are associated with significant morbidity and mortality. It is shown that by trapping a sub-millimeter clinical catheter inside the aneurysm sac using a flow diverter stent (FDS), instant hemostasis can be achieved by filling the aneurysm sac using a novel biomaterial, rescuing catastrophic bleeding in large-animal models. Multiple formulations of a biomaterial comprising gelatin, nanoclay (NC), and iohexol are developed, optimized, and extensively tested in vitro to select the lead candidate for further testing in vivo in murine, porcine, and canine models of WNAs, including in a subset with aneurysm rupture. The catheter-injectable and X-ray visible versions of the gel embolic agent (GEA) with the optimized mechanical properties outperform control groups, including a subset that receive a clinically used liquid embolic (Onyx, Medtronic), with and without aneurysm rupture. A combinatorial approach to ruptured WNAs with GEA and FDS may change the standard of medical practice and save lives
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|a Journal Article
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|a aneurysms
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4 |
|a biomaterials
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4 |
|a catheters
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| 650 |
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4 |
|a hemorrhage
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| 650 |
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|a rupture
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4 |
|a stents
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| 650 |
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4 |
|a wide-neck
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1 |
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|a Albadawi, Hassan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fowl, Richard J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mayer, Joseph L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chong, Brian W
|e verfasserin
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| 700 |
1 |
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|a Oklu, Rahmi
|e verfasserin
|4 aut
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 46 vom: 01. Nov., Seite e2305868
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|g volume:35
|g year:2023
|g number:46
|g day:01
|g month:11
|g pages:e2305868
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|u http://dx.doi.org/10.1002/adma.202305868
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