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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202303562
|2 doi
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|a pubmed24n1200.xml
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|e rakwb
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|a eng
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|a Pang, Zeyang
|e verfasserin
|4 aut
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|a Tuning Ligands Ratio Allows for Controlling Gold Nanocluster Conformation and Activating a Nonantimicrobial Thiol Fragrance for Effective Treatment of MRSA-Induced Keratitis
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Revised 04.10.2023
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a © 2023 Wiley-VCH GmbH.
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|a Bacterial keratitis is a serious ocular disease that affects millions of people worldwide each year, among which ≈25% are caused by Staphylococcus aureus. With the spread of bacterial resistance, refractory keratitis caused by methicillin-resistant S. aureus (MRSA) affects ≈120 000-190 000 people annually and is a significant cause of infectious blindness. Atomically precise gold nanoclusters (GNCs) recently emerged as promising antibacterial agents; although how the GNC structure and capping ligands control the antibacterial properties remains largely unexplored. In this study, by adjusting the ratio of a "bulky" thiol fragrance to a linear zwitterionic ligand, the GNC conformation is transformed from Au25 (SR)18 to Au23 (SR)16 species, simultaneously converting both inactive thiol ligands into potent antibacterial nanomaterials. Surprisingly, mixed-ligand capped Au23 (SR)16 GNCs exhibit superior antibacterial potency compared to their monoligand counterparts. The optimal GNC is highly potent against MRSA, showing >1024-fold lower minimum inhibitory concentration than the corresponding free ligands. Moreover, it displays excellent potency in treating MRSA-induced keratitis in mice with greatly accelerated corneal recovery (by approximately ninefold). Thus, this study establishes a feasible method to synthesize antibacterial GNCs by adjusting the ligand ratio to control GNC conformation and active non-antibacterial ligands, thereby greatly increasing the repertoires for combating multidrug-resistant bacterial infections
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|a Journal Article
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|a antibiotic resistance
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|a bacterial keratitis
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|a gold nanoclusters
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| 650 |
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|a ocular therapeutics
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| 650 |
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|a thiol fragrance
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| 650 |
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4 |
|a zwitterion ligands
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| 700 |
1 |
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|a Ren, Ning
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Yujie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qi, Jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Fupin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guo, Yuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Yangzhouyun
|e verfasserin
|4 aut
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| 700 |
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|a Zhou, Dejian
|e verfasserin
|4 aut
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| 700 |
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|a Jiang, Xingyu
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 40 vom: 29. Okt., Seite e2303562
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:35
|g year:2023
|g number:40
|g day:29
|g month:10
|g pages:e2303562
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|u http://dx.doi.org/10.1002/adma.202303562
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