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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/aah.10195
|2 doi
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|a pubmed24n1235.xml
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|a (DE-627)NLM360015255
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|a (NLM)37501608
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Chiejina, Chike Obinna
|e verfasserin
|4 aut
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| 245 |
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|a Effects of haloperidol on peripheral erythrocytes and brain neurotransmitter levels of juvenile African Sharptooth Catfish Clarias gariepinus
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 22.12.2023
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|a Date Revised 22.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 American Fisheries Society.
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|a OBJECTIVE: The study investigated the effects of haloperidol on peripheral erythrocytes and brain neurotransmitter levels of juvenile African Sharptooth Catfish Clarias gariepinus
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|a METHODS: Juveniles were exposed to different concentrations of haloperidol (0.12, 0.24, and 0.48 mg/L) for 15 days and subsequently withdrawn from the drug for 5 days. Blood samples from the fish on days 1, 5, 10, and 15 and after the 5-day withdrawal period were analyzed for mutagenic changes, after which the fish were sacrificed. The brain was sampled for serotonergic and dopaminergic analyses
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|a RESULT: There was formation of micronuclei in the peripheral fish blood, which increased as the duration and concentrations of the drug increased. The drug significantly reduced the serotonin activity but increased dopamine activity. Some of the studied parameters, however, recovered from the effects of the drug after the 5-day withdrawal period
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|a CONCLUSION: Haloperidol is toxic to fish, and its use in the environment should be guarded to avoid adverse impacts on nontarget species like fish
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4 |
|a Journal Article
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4 |
|a antipsychotic drug
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|a fish
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| 650 |
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|a genotoxicity
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| 650 |
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4 |
|a neurotransmitters
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| 650 |
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|a recovery
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| 650 |
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|a Haloperidol
|2 NLM
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| 650 |
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7 |
|a J6292F8L3D
|2 NLM
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| 650 |
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|a Water Pollutants, Chemical
|2 NLM
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| 700 |
1 |
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|a Ikeh, Ifeanyi Mulumba
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Enebe, Florence A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Aguzie, Ifeanyi Oscar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ajima, Malachy Nwigwe Okechukwu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ali, Daoud
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kumar, Gokhlesh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nwani, Christopher Didigwu
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Journal of aquatic animal health
|d 1998
|g 35(2023), 4 vom: 28. Dez., Seite 238-247
|w (DE-627)NLM098202006
|x 1548-8667
|7 nnns
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| 773 |
1 |
8 |
|g volume:35
|g year:2023
|g number:4
|g day:28
|g month:12
|g pages:238-247
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|u http://dx.doi.org/10.1002/aah.10195
|3 Volltext
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|a AR
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|d 35
|j 2023
|e 4
|b 28
|c 12
|h 238-247
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