Effects of haloperidol on peripheral erythrocytes and brain neurotransmitter levels of juvenile African Sharptooth Catfish Clarias gariepinus
© 2023 American Fisheries Society.
| Publié dans: | Journal of aquatic animal health. - 1998. - 35(2023), 4 vom: 15. Dez., Seite 238-247 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2023
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| Accès à la collection: | Journal of aquatic animal health |
| Sujets: | Journal Article antipsychotic drug fish genotoxicity neurotransmitters recovery Haloperidol J6292F8L3D Water Pollutants, Chemical |
| Résumé: | © 2023 American Fisheries Society. OBJECTIVE: The study investigated the effects of haloperidol on peripheral erythrocytes and brain neurotransmitter levels of juvenile African Sharptooth Catfish Clarias gariepinus METHODS: Juveniles were exposed to different concentrations of haloperidol (0.12, 0.24, and 0.48 mg/L) for 15 days and subsequently withdrawn from the drug for 5 days. Blood samples from the fish on days 1, 5, 10, and 15 and after the 5-day withdrawal period were analyzed for mutagenic changes, after which the fish were sacrificed. The brain was sampled for serotonergic and dopaminergic analyses RESULT: There was formation of micronuclei in the peripheral fish blood, which increased as the duration and concentrations of the drug increased. The drug significantly reduced the serotonin activity but increased dopamine activity. Some of the studied parameters, however, recovered from the effects of the drug after the 5-day withdrawal period CONCLUSION: Haloperidol is toxic to fish, and its use in the environment should be guarded to avoid adverse impacts on nontarget species like fish |
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| Description: | Date Completed 22.12.2023 Date Revised 02.01.2024 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1548-8667 |
| DOI: | 10.1002/aah.10195 |