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|a 10.1002/adma.202302069
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|a eng
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|a Nguyen, Van Phuc
|e verfasserin
|4 aut
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|a Renally Clearable Ultraminiature Chain-Like Gold Nanoparticle Clusters for Multimodal Molecular Imaging of Choroidal Neovascularization
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|c 2023
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 04.08.2023
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|a Date Revised 02.08.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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|a Currently, available gold nanoparticles (GNPs) typically accumulate in the liver and spleen, leading to concerns for their long-term biosafety. To address this long-standing problem, ultraminiature chain-like gold nanoparticle clusters (GNCs) are developed. Via self-assembly of 7-8 nm GNP monomers, GNCs provide redshifted optical absorption and scattering contrast in the near-infrared window. After disassembly, GNCs turn back to GNPs with a size smaller than the renal glomerular filtration size cutoff, allowing their excretion via urine. A one-month longitudinal study in a rabbit eye model demonstrates that GNCs facilitate multimodal molecular imaging of choroidal neovascularization (CNV) in vivo, non-invasively, with excellent sensitivity and spatial resolution. GNCs targeting αv β3 integrins enhance photoacoustic and optical coherence tomography (OCT) signals from CNV by 25.3-fold and 150%, respectively. With excellent biosafety and biocompatibility demonstrated, GNCs render a first-of-its-kind nanoplatform for biomedical imaging
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|a Journal Article
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|a age-related macular degeneration
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|a contrast agents
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|a multimodality molecular ocular imaging
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|a optical coherence tomography
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|a photoacoustic microscopy
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|a renally clearable ultraminiature chain-like gold nanoparticles
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|a retinal diseases
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|a Gold
|2 NLM
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|a 7440-57-5
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| 700 |
1 |
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|a Qian, Wei
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1 |
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|a Zhe, Josh
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1 |
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|a Henry, Jessica
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1 |
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|a Wang, Mingyang
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| 700 |
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|a Liu, Bing
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| 700 |
1 |
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|a Zhang, Wei
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|a Wang, Xueding
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|a Paulus, Yannis M
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