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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c00834
|2 doi
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|a pubmed25n1189.xml
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|a (DE-627)NLM356983854
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|a (NLM)37195813
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|a DE-627
|b ger
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhang, Jiaojiao
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Self-Assembly of Peptide-Lipid Nanoparticles for the Efficient Delivery of Nucleic Acids
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| 264 |
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|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 31.05.2023
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|a Date Revised 31.05.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a A transfection formulation is successfully developed to deliver nucleic acids by adding an auxiliary lipid (DOTAP) to the peptide, and the transfection efficiency of pDNA reaches 72.6%, which is close to Lipofectamine 2000. In addition, the designed KHL peptide-DOTAP complex exhibits good biocompatibility by cytotoxicity and hemolysis analysis. The mRNA delivery experiment indicates that the complex had a 9- or 10-fold increase compared with KHL or DOTAP alone. Intracellular localization shows that KHL/DOTAP can achieve good endolysosomal escape. Our design provides a new platform for improving the transfection efficiency of peptide vectors
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Lipid Nanoparticles
|2 NLM
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| 650 |
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|a Nucleic Acids
|2 NLM
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| 650 |
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|a 1,2-dioleoyloxy-3-(trimethylammonium)propane
|2 NLM
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| 650 |
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|a MR86K0XRQP
|2 NLM
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| 650 |
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|a Liposomes
|2 NLM
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| 650 |
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|a Peptides
|2 NLM
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| 700 |
1 |
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|a Wang, Zixuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Min, Jiwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xuelin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Su, Rongxin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yuefei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qi, Wei
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 39(2023), 21 vom: 30. Mai, Seite 7484-7494
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
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|g volume:39
|g year:2023
|g number:21
|g day:30
|g month:05
|g pages:7484-7494
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|u http://dx.doi.org/10.1021/acs.langmuir.3c00834
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