Single and joint toxic effects of thyroid hormone, levothyroxine, and amiodarone on embryo-larval stages of zebrafish (Danio rerio)

Single and joint toxic effects of thyroid hormone, levothyroxine, and amiodarone on embryo-larval stages of zebrafish (Danio rerio)

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Détails bibliographiques
Publié dans:Ecotoxicology (London, England). - 1992. - 32(2023), 4 vom: 29. Mai, Seite 525-535
Auteur principal: Santos, Thamiris Pinheiro (Auteur)
Autres auteurs: da Silva Bastos, Paulo Eduardo, da Silva, Jadson Freitas, de Medeiros Vieira, Stefânia Maria, da Silva, Marília Cordeiro Galvão, de Andrade, André Lucas Corrêa, Padilha, Renata Meireles Oliveira, Dos Santos Magnabosco, Amanda Rodrigues, Cadena, Marilia Ribeiro Sales, Cadena, Pabyton Gonçalves
Format: Article en ligne
Langue:English
Publié: 2023
Accès à la collection:Ecotoxicology (London, England)
Sujets:Journal Article Antagonistic effect Aquatic animals Developmental toxicity Endocrine disruptors Zebrafish Thyroxine Q51BO43MG4 Amiodarone N3RQ532IUT plus... Thyroid Hormones Water Pollutants, Chemical
Description
Résumé:© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
This study evaluates single and joint endocrine disruptor toxicities of thyroid hormone, levothyroxine, and amiodarone in the embryo-larval stages of Danio rerio. Single toxicity experiments were carried out in concentrations based on the environmental concentration and increasing concentrations of 10, 100, and 1000 times the environmental concentration. Joint toxicity experiments evaluated the combined effects of these compounds. Toxic effects were examined during zebrafish embryonic development, and the parameters analyzed were apical sublethal, teratogenicity, mortality endpoints, and morphometry. Thyroid hormone exhibited the highest toxicity. However, the results showed that the environmental concentrations for all 3 compounds had low risk in relation to the parameters studied, such as teratogenic effects and morphometry. The larvae were more affected than embryos, where embryos needed higher concentrations in all experiments, possibly due to the absence of the chorion. The same type of effects were observed in the joint toxicity test, except that a possible antagonistic effect was detected. However, high concentrations showed stronger effects of these toxic compounds on fish development
Description:Date Completed 22.05.2023
Date Revised 22.05.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1573-3017
DOI:10.1007/s10646-023-02655-6