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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-023-02655-6
|2 doi
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|a pubmed24n1187.xml
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|a (DE-627)NLM356228207
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|a (NLM)37119427
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Santos, Thamiris Pinheiro
|e verfasserin
|4 aut
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| 245 |
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|a Single and joint toxic effects of thyroid hormone, levothyroxine, and amiodarone on embryo-larval stages of zebrafish (Danio rerio)
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 22.05.2023
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|a Date Revised 22.05.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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|a This study evaluates single and joint endocrine disruptor toxicities of thyroid hormone, levothyroxine, and amiodarone in the embryo-larval stages of Danio rerio. Single toxicity experiments were carried out in concentrations based on the environmental concentration and increasing concentrations of 10, 100, and 1000 times the environmental concentration. Joint toxicity experiments evaluated the combined effects of these compounds. Toxic effects were examined during zebrafish embryonic development, and the parameters analyzed were apical sublethal, teratogenicity, mortality endpoints, and morphometry. Thyroid hormone exhibited the highest toxicity. However, the results showed that the environmental concentrations for all 3 compounds had low risk in relation to the parameters studied, such as teratogenic effects and morphometry. The larvae were more affected than embryos, where embryos needed higher concentrations in all experiments, possibly due to the absence of the chorion. The same type of effects were observed in the joint toxicity test, except that a possible antagonistic effect was detected. However, high concentrations showed stronger effects of these toxic compounds on fish development
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|a Journal Article
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|a Antagonistic effect
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|a Aquatic animals
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|a Developmental toxicity
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|a Endocrine disruptors
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|a Zebrafish
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| 650 |
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|a Thyroxine
|2 NLM
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| 650 |
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|a Q51BO43MG4
|2 NLM
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| 650 |
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|a Amiodarone
|2 NLM
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| 650 |
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|a N3RQ532IUT
|2 NLM
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| 650 |
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|a Thyroid Hormones
|2 NLM
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| 650 |
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|a Water Pollutants, Chemical
|2 NLM
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| 700 |
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|a da Silva Bastos, Paulo Eduardo
|e verfasserin
|4 aut
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| 700 |
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|a da Silva, Jadson Freitas
|e verfasserin
|4 aut
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| 700 |
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|a de Medeiros Vieira, Stefânia Maria
|e verfasserin
|4 aut
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| 700 |
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|a da Silva, Marília Cordeiro Galvão
|e verfasserin
|4 aut
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| 700 |
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|a de Andrade, André Lucas Corrêa
|e verfasserin
|4 aut
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| 700 |
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|a Padilha, Renata Meireles Oliveira
|e verfasserin
|4 aut
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| 700 |
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|a Dos Santos Magnabosco, Amanda Rodrigues
|e verfasserin
|4 aut
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| 700 |
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|a Cadena, Marilia Ribeiro Sales
|e verfasserin
|4 aut
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| 700 |
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|a Cadena, Pabyton Gonçalves
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 32(2023), 4 vom: 29. Mai, Seite 525-535
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:32
|g year:2023
|g number:4
|g day:29
|g month:05
|g pages:525-535
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|u http://dx.doi.org/10.1007/s10646-023-02655-6
|3 Volltext
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