Serum soluble mediators as prognostic biomarkers for morbidity, disease outcome, and late-relapsing hepatitis in yellow fever patients

Serum soluble mediators as prognostic biomarkers for morbidity, disease outcome, and late-relapsing hepatitis in yellow fever patients

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 251(2023) vom: 01. Juni, Seite 109321
1. Verfasser: Fradico, Jordana Rodrigues Barbosa (VerfasserIn)
Weitere Verfasser: Campi-Azevedo, Ana Carolina, Speziali, Elaine, do Valle Antonelli, Lis Ribeiro, Peruhype-Magalhães, Vanessa, de Rezende, Izabela Maurício, Alves, Pedro Augusto, Pascoal-Xavier, Marcelo Antônio, Pereira, Leonardo Soares, Dutra, Maria Rita Teixeira, Ramalho, Dario Brock, Cenachi, Adriana, de Paula, Ludmila, Santos, Tayrine Araujo, do Carmo Said, Rodrigo Fabiano, Calzavara-Silva, Carlos Eduardo, Coelho-Dos-Reis, Jordana Grazziela Alves, de Magalhães, Clara Ramos, Rabelo, Lara Luíza Cerávolo, Valim, Valéria, Brito-de-Sousa, Joaquim Pedro, da Costa-Rocha, Ismael Artur, de Souza Gomes, Matheus, Amaral, Laurence Rodrigues, de Lima, Sheila Maria Barbosa, Trindade, Gisela Freitas, Santos, Renata Tourinho, da Silva, Juliana Fernandes Amorim, Monath, Thomas, LaBeaud, Angelle Desiree, Drumond, Betânia Paiva, Martins-Filho, Olindo Assis, Teixeira-Carvalho, Andréa, Yellow Fever Collaborative Group
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Chemokines Cytokines Late hepatitis Prognostic biomarkers Yellow fever Biomarkers Yellow Fever Vaccine
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100 1 |a Fradico, Jordana Rodrigues Barbosa  |e verfasserin  |4 aut 
245 1 0 |a Serum soluble mediators as prognostic biomarkers for morbidity, disease outcome, and late-relapsing hepatitis in yellow fever patients 
264 1 |c 2023 
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500 |a Date Completed 23.05.2023 
500 |a Date Revised 23.05.2023 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2023. Published by Elsevier Inc. 
520 |a This study described a soluble mediator storm in acute Yellow Fever/YF infection along the kinetics timeline towards convalescent disease. The analyses of the YF Viral RNAnemia, chemokines, cytokines, and growth factors were performed in YF patients at acute/(D1-15) and convalescent/(D16-315) phases. Patients with acute YF infection displayed a trimodal viremia profile spreading along D3, D6, and D8-14. A massive storm of mediators was observed in acute YF. Higher levels of mediators were observed in YF with higher morbidity scores, patients under intensive care, and those progressing to death than in YF patients who progress to late-relapsing hepatitis/L-Hep. A unimodal peak of biomarkers around D4-6 with a progressive decrease towards D181-315 was observed in non-L-Hep patients, while a bimodal pattern with a second peak around D61-90 was associated with L-Hep. This study provided a comprehensive landscape of evidence that distinct immune responses drive pathogenesis, disease progression, and L-Hep in YF patients 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Chemokines 
650 4 |a Cytokines 
650 4 |a Late hepatitis 
650 4 |a Prognostic biomarkers 
650 4 |a Yellow fever 
650 7 |a Cytokines  |2 NLM 
650 7 |a Biomarkers  |2 NLM 
650 7 |a Yellow Fever Vaccine  |2 NLM 
700 1 |a Campi-Azevedo, Ana Carolina  |e verfasserin  |4 aut 
700 1 |a Speziali, Elaine  |e verfasserin  |4 aut 
700 1 |a do Valle Antonelli, Lis Ribeiro  |e verfasserin  |4 aut 
700 1 |a Peruhype-Magalhães, Vanessa  |e verfasserin  |4 aut 
700 1 |a de Rezende, Izabela Maurício  |e verfasserin  |4 aut 
700 1 |a Alves, Pedro Augusto  |e verfasserin  |4 aut 
700 1 |a Pascoal-Xavier, Marcelo Antônio  |e verfasserin  |4 aut 
700 1 |a Pereira, Leonardo Soares  |e verfasserin  |4 aut 
700 1 |a Dutra, Maria Rita Teixeira  |e verfasserin  |4 aut 
700 1 |a Ramalho, Dario Brock  |e verfasserin  |4 aut 
700 1 |a Cenachi, Adriana  |e verfasserin  |4 aut 
700 1 |a de Paula, Ludmila  |e verfasserin  |4 aut 
700 1 |a Santos, Tayrine Araujo  |e verfasserin  |4 aut 
700 1 |a do Carmo Said, Rodrigo Fabiano  |e verfasserin  |4 aut 
700 1 |a Calzavara-Silva, Carlos Eduardo  |e verfasserin  |4 aut 
700 1 |a Coelho-Dos-Reis, Jordana Grazziela Alves  |e verfasserin  |4 aut 
700 1 |a de Magalhães, Clara Ramos  |e verfasserin  |4 aut 
700 1 |a Rabelo, Lara Luíza Cerávolo  |e verfasserin  |4 aut 
700 1 |a Valim, Valéria  |e verfasserin  |4 aut 
700 1 |a Brito-de-Sousa, Joaquim Pedro  |e verfasserin  |4 aut 
700 1 |a da Costa-Rocha, Ismael Artur  |e verfasserin  |4 aut 
700 1 |a de Souza Gomes, Matheus  |e verfasserin  |4 aut 
700 1 |a Amaral, Laurence Rodrigues  |e verfasserin  |4 aut 
700 1 |a de Lima, Sheila Maria Barbosa  |e verfasserin  |4 aut 
700 1 |a Trindade, Gisela Freitas  |e verfasserin  |4 aut 
700 1 |a Santos, Renata Tourinho  |e verfasserin  |4 aut 
700 1 |a da Silva, Juliana Fernandes Amorim  |e verfasserin  |4 aut 
700 1 |a Monath, Thomas  |e verfasserin  |4 aut 
700 1 |a LaBeaud, Angelle Desiree  |e verfasserin  |4 aut 
700 1 |a Drumond, Betânia Paiva  |e verfasserin  |4 aut 
700 1 |a Martins-Filho, Olindo Assis  |e verfasserin  |4 aut 
700 1 |a Teixeira-Carvalho, Andréa  |e verfasserin  |4 aut 
700 0 |a Yellow Fever Collaborative Group  |e verfasserin  |4 aut 
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