Serum soluble mediators as prognostic biomarkers for morbidity, disease outcome, and late-relapsing hepatitis in yellow fever patients

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 251(2023) vom: 01. Juni, Seite 109321
1. Verfasser:	Fradico, Jordana Rodrigues Barbosa (VerfasserIn)
Weitere Verfasser:	Campi-Azevedo, Ana Carolina, Speziali, Elaine, do Valle Antonelli, Lis Ribeiro, Peruhype-Magalhães, Vanessa, de Rezende, Izabela Maurício, Alves, Pedro Augusto, Pascoal-Xavier, Marcelo Antônio, Pereira, Leonardo Soares, Dutra, Maria Rita Teixeira, Ramalho, Dario Brock, Cenachi, Adriana, de Paula, Ludmila, Santos, Tayrine Araujo, do Carmo Said, Rodrigo Fabiano, Calzavara-Silva, Carlos Eduardo, Coelho-Dos-Reis, Jordana Grazziela Alves, de Magalhães, Clara Ramos, Rabelo, Lara Luíza Cerávolo, Valim, Valéria, Brito-de-Sousa, Joaquim Pedro, da Costa-Rocha, Ismael Artur, de Souza Gomes, Matheus, Amaral, Laurence Rodrigues, de Lima, Sheila Maria Barbosa, Trindade, Gisela Freitas, Santos, Renata Tourinho, da Silva, Juliana Fernandes Amorim, Monath, Thomas, LaBeaud, Angelle Desiree, Drumond, Betânia Paiva, Martins-Filho, Olindo Assis, Teixeira-Carvalho, Andréa, Yellow Fever Collaborative Group
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2023
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Chemokines Cytokines Late hepatitis Prognostic biomarkers Yellow fever Biomarkers Yellow Fever Vaccine

Beschreibung
Zusammenfassung:	Copyright © 2023. Published by Elsevier Inc. This study described a soluble mediator storm in acute Yellow Fever/YF infection along the kinetics timeline towards convalescent disease. The analyses of the YF Viral RNAnemia, chemokines, cytokines, and growth factors were performed in YF patients at acute/(D1-15) and convalescent/(D16-315) phases. Patients with acute YF infection displayed a trimodal viremia profile spreading along D3, D6, and D8-14. A massive storm of mediators was observed in acute YF. Higher levels of mediators were observed in YF with higher morbidity scores, patients under intensive care, and those progressing to death than in YF patients who progress to late-relapsing hepatitis/L-Hep. A unimodal peak of biomarkers around D4-6 with a progressive decrease towards D181-315 was observed in non-L-Hep patients, while a bimodal pattern with a second peak around D61-90 was associated with L-Hep. This study provided a comprehensive landscape of evidence that distinct immune responses drive pathogenesis, disease progression, and L-Hep in YF patients
Beschreibung:	Date Completed 23.05.2023 Date Revised 23.05.2023 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2023.109321