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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202302335
|2 doi
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|a pubmed25n1183.xml
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|a (DE-627)NLM355005824
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|a (NLM)36995655
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|e rakwb
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|a eng
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|a Ai, Yongjian
|e verfasserin
|4 aut
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|a Ultra-Small High-Entropy Alloy Nanoparticles
|b Efficient Nanozyme for Enhancing Tumor Photothermal Therapy
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 09.06.2023
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|a Date Revised 09.06.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a High-entropy alloys nanoparticles (HEANPs) are receiving extensive attention due to their broad compositional tunability and unlimited potential in bioapplication. However, developing new methods to prepare ultra-small high-entropy alloy nanoparticles (US-HEANPs) faces severe challenges owing to their intrinsic thermodynamic instability. Furthermore, there are few reports on studying the effect of HEANPs in tumor therapy. Herein, the fabricated PtPdRuRhIr US-HEANPs act as bifunctional nanoplatforms for the highly efficient treatment of tumors. The US-HEANPs are engineered by the universal metal-ligand cross-linking strategy. This simple and scalable strategy is based on the aldol condensation of organometallics to form the target US-HEANPs. The synthesized US-HEANPs exhibit excellent peroxidase-like (POD-like) activity and can catalyze the endogenous hydrogen peroxide to produce highly toxic hydroxyl radicals. Furthermore, the US-HEANPs possess a high photothermal conversion effect for converting 808 nm near-infrared light into heat energy. In vivo and in vitro experiments demonstrated that under the synergistic effect of POD-like activity and photothermal action, the US-HEANPs can effectively ablate cancer cells and treat tumors. It is believed that this work not only provides a new perspective for the fabrication of HEANPs, but also opens the high-entropy nanozymes research direction and their biomedical application
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|a Journal Article
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|a high-entropy alloy nanozymes
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|a metal-ligand cross-linking strategies
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|a photothermal therapy
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|a tumor therapy
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|a ultra-small high-entropy alloy
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7 |
|a Alloys
|2 NLM
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|a Hydrogen Peroxide
|2 NLM
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| 650 |
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|a BBX060AN9V
|2 NLM
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| 700 |
1 |
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|a He, Meng-Qi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jia, Xiaomeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xinyue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Hong-Bin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liang, Qionglin
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 23 vom: 30. Juni, Seite e2302335
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:35
|g year:2023
|g number:23
|g day:30
|g month:06
|g pages:e2302335
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|u http://dx.doi.org/10.1002/adma.202302335
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