Immune tolerance breakdown in inborn errors of immunity Paving the way to novel therapeutic approaches

Immune tolerance breakdown in inborn errors of immunity : Paving the way to novel therapeutic approaches

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 251(2023) vom: 24. Juni, Seite 109302
1. Verfasser: Giardino, Giuliana (VerfasserIn)
Weitere Verfasser: Romano, Roberta, Lougaris, Vassilios, Castagnoli, Riccardo, Cillo, Francesca, Leonardi, Lucia, La Torre, Francesco, Soresina, Annarosa, Federici, Silvia, Cancrini, Caterina, Pacillo, Lucia, Toriello, Elisabetta, Cinicola, Bianca Laura, Corrente, Stefania, Volpi, Stefano, Marseglia, Gian Luigi, Pignata, Claudio, Cardinale, Fabio, Immunology Task Force of the Italian Society of Pediatric Allergy and Immunology (SIAIP)
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Review Autoimmunity Immune tolerance Immunodysregulation Inborn errors of immunity T Reg
Beschreibung
Zusammenfassung:Copyright © 2023. Published by Elsevier Inc.
Up to 25% of the patients with inborn errors of immunity (IEI) also exhibit immunodysregulatory features. The association of immune dysregulation and immunodeficiency may be explained by different mechanisms. The understanding of mechanisms underlying immune dysregulation in IEI has paved the way for the development of targeted treatments. In this review article, we will summarize the mechanisms of immune tolerance breakdown and the targeted therapeutic approaches to immune dysregulation in IEI
Beschreibung:Date Completed 25.05.2023
Date Revised 25.05.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109302