Immune tolerance breakdown in inborn errors of immunity Paving the way to novel therapeutic approaches

Immune tolerance breakdown in inborn errors of immunity : Paving the way to novel therapeutic approaches

Copyright © 2023. Published by Elsevier Inc.

Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 251(2023) vom: 24. Juni, Seite 109302
Auteur principal: Giardino, Giuliana (Auteur)
Autres auteurs: Romano, Roberta, Lougaris, Vassilios, Castagnoli, Riccardo, Cillo, Francesca, Leonardi, Lucia, La Torre, Francesco, Soresina, Annarosa, Federici, Silvia, Cancrini, Caterina, Pacillo, Lucia, Toriello, Elisabetta, Cinicola, Bianca Laura, Corrente, Stefania, Volpi, Stefano, Marseglia, Gian Luigi, Pignata, Claudio, Cardinale, Fabio, Immunology Task Force of the Italian Society of Pediatric Allergy and Immunology (SIAIP)
Format: Article en ligne
Langue:English
Publié: 2023
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Review Autoimmunity Immune tolerance Immunodysregulation Inborn errors of immunity T Reg
Description
Résumé:Copyright © 2023. Published by Elsevier Inc.
Up to 25% of the patients with inborn errors of immunity (IEI) also exhibit immunodysregulatory features. The association of immune dysregulation and immunodeficiency may be explained by different mechanisms. The understanding of mechanisms underlying immune dysregulation in IEI has paved the way for the development of targeted treatments. In this review article, we will summarize the mechanisms of immune tolerance breakdown and the targeted therapeutic approaches to immune dysregulation in IEI
Description:Date Completed 25.05.2023
Date Revised 25.05.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109302