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20231226060807.0 |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109276
|2 doi
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|a pubmed24n1179.xml
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|a (DE-627)NLM353776483
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|a (NLM)36871764
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|a (PII)S1521-6616(23)00055-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Rath, Eivind
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Systemic immune activation profiles in streptococcal necrotizing soft tissue infections
|b A prospective multicenter study
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1 |
|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 04.04.2023
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|a Date Revised 11.04.2023
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|a published: Print-Electronic
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|a Dryad: 10.5061/dryad.f1vhhmgw4
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|a Citation Status MEDLINE
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|a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
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|a OBJECTIVE: Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in streptococcal disease may guide correct interventions and discovery of novel diagnostic targets
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|a METHODS: Plasma levels of 37 mediators, leucocytes and CRP from 102 patients with β-hemolytic streptococcal NSTI derived from a prospective Scandinavian multicentre study were compared to those of 23 cases of streptococcal cellulitis. Hierarchical cluster analyses were also performed
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| 520 |
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|a RESULTS: Differences in mediator levels between NSTI and cellulitis cases were revealed, in particular for IL-1β, TNFα and CXCL8 (AUC >0.90). Across streptococcal NSTI etiologies, eight biomarkers separated cases with septic shock from those without, and four mediators predicted a severe outcome
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| 520 |
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|a CONCLUSION: Several inflammatory mediators and wider profiles were identified as potential biomarkers of NSTI. Associations of biomarker levels to type of infection and outcomes may be utilized to improve patient care and outcomes
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|a Multicenter Study
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Biomarker
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| 650 |
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|a Cellulitis
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| 650 |
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4 |
|a NSTI
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| 650 |
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|a Necrotizing fasciitis
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| 650 |
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4 |
|a Streptococcus dysgalactiae
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| 650 |
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|a Streptococcus pyogenes
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| 650 |
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|a Biomarkers
|2 NLM
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| 700 |
1 |
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|a Palma Medina, Laura M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jahagirdar, Sanjeevan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mosevoll, Knut A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Damås, Jan K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Madsen, Martin B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Svensson, Mattias
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hyldegaard, Ole
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Martins Dos Santos, Vitor A P
|e verfasserin
|4 aut
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| 700 |
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|a INFECT Study group
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Saccenti, Edoardo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Norrby-Teglund, Anna
|e verfasserin
|4 aut
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| 700 |
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|a Skrede, Steinar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bruun, Trond
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 249(2023) vom: 01. Apr., Seite 109276
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:249
|g year:2023
|g day:01
|g month:04
|g pages:109276
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2023.109276
|3 Volltext
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