Systemic immune activation profiles in streptococcal necrotizing soft tissue infections A prospective multicenter study

Systemic immune activation profiles in streptococcal necrotizing soft tissue infections : A prospective multicenter study

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 249(2023) vom: 01. Apr., Seite 109276
1. Verfasser: Rath, Eivind (VerfasserIn)
Weitere Verfasser: Palma Medina, Laura M, Jahagirdar, Sanjeevan, Mosevoll, Knut A, Damås, Jan K, Madsen, Martin B, Svensson, Mattias, Hyldegaard, Ole, Martins Dos Santos, Vitor A P, INFECT Study group, Saccenti, Edoardo, Norrby-Teglund, Anna, Skrede, Steinar, Bruun, Trond
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Multicenter Study Journal Article Research Support, Non-U.S. Gov't Biomarker Cellulitis NSTI Necrotizing fasciitis Streptococcus dysgalactiae Streptococcus pyogenes Biomarkers
Beschreibung
Zusammenfassung:Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in streptococcal disease may guide correct interventions and discovery of novel diagnostic targets
METHODS: Plasma levels of 37 mediators, leucocytes and CRP from 102 patients with β-hemolytic streptococcal NSTI derived from a prospective Scandinavian multicentre study were compared to those of 23 cases of streptococcal cellulitis. Hierarchical cluster analyses were also performed
RESULTS: Differences in mediator levels between NSTI and cellulitis cases were revealed, in particular for IL-1β, TNFα and CXCL8 (AUC >0.90). Across streptococcal NSTI etiologies, eight biomarkers separated cases with septic shock from those without, and four mediators predicted a severe outcome
CONCLUSION: Several inflammatory mediators and wider profiles were identified as potential biomarkers of NSTI. Associations of biomarker levels to type of infection and outcomes may be utilized to improve patient care and outcomes
Beschreibung:Date Completed 04.04.2023
Date Revised 11.04.2023
published: Print-Electronic
Dryad: 10.5061/dryad.f1vhhmgw4
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109276