Geometric Tuning of Single-Atom FeN4 Sites via Edge-Generation Enhances Multi-Enzymatic Properties

Geometric Tuning of Single-Atom FeN4 Sites via Edge-Generation Enhances Multi-Enzymatic Properties

© 2023 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 19 vom: 14. Mai, Seite e2207666
1. Verfasser: Kim, Kang (VerfasserIn)
Weitere Verfasser: Lee, Jaewoo, Park, Ok Kyu, Kim, Jongseung, Kim, Jiheon, Lee, Donghyun, Paidi, Vinod K, Jung, Euiyeon, Lee, Hyeon Seok, Lee, Bowon, Lee, Chan Woo, Ko, Wonjae, Lee, Kangjae, Jung, Yoon, Lee, Changha, Lee, Nohyun, Back, Seoin, Choi, Seung Hong, Hyeon, Taeghwan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article catalytic tumor therapy edge-generation peroxidase-like activity single-atom nanozymes structure-activity relationship Coloring Agents Peroxidase EC 1.11.1.7 Peroxidases EC 1.11.1.-
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520 |a Single-atom nanozymes (SAzymes) are considered promising alternatives to natural enzymes. The catalytic performance of SAzymes featuring homogeneous, well-defined active structures can be enhanced through elucidating structure-activity relationship and tailoring physicochemical properties. However, manipulating enzymatic properties through structural variation is an underdeveloped approach. Herein, the synthesis of edge-rich Fe single-atom nanozymes (FeNC-edge) via an H2 O2 -mediated edge generation is reported. By controlling the number of edge sites, the peroxidase (POD)- and oxidase (OXD)-like performance is significantly enhanced. The activity enhancement results from the presence of abundant edges, which provide new anchoring sites to mononuclear Fe. Experimental results combined with density functional theory (DFT) calculations reveal that FeN4 moieties in the edge sites display high electron density of Fe atoms and open N atoms. Finally, it is demonstrated that FeNC-edge nanozyme effectively inhibits tumor growth both in vitro and in vivo, suggesting that edge-tailoring is an efficient strategy for developing artificial enzymes as novel catalytic therapeutics 
650 4 |a Journal Article 
650 4 |a catalytic tumor therapy 
650 4 |a edge-generation 
650 4 |a peroxidase-like activity 
650 4 |a single-atom nanozymes 
650 4 |a structure-activity relationship 
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650 7 |a Peroxidase  |2 NLM 
650 7 |a EC 1.11.1.7  |2 NLM 
650 7 |a Peroxidases  |2 NLM 
650 7 |a EC 1.11.1.-  |2 NLM 
700 1 |a Lee, Jaewoo  |e verfasserin  |4 aut 
700 1 |a Park, Ok Kyu  |e verfasserin  |4 aut 
700 1 |a Kim, Jongseung  |e verfasserin  |4 aut 
700 1 |a Kim, Jiheon  |e verfasserin  |4 aut 
700 1 |a Lee, Donghyun  |e verfasserin  |4 aut 
700 1 |a Paidi, Vinod K  |e verfasserin  |4 aut 
700 1 |a Jung, Euiyeon  |e verfasserin  |4 aut 
700 1 |a Lee, Hyeon Seok  |e verfasserin  |4 aut 
700 1 |a Lee, Bowon  |e verfasserin  |4 aut 
700 1 |a Lee, Chan Woo  |e verfasserin  |4 aut 
700 1 |a Ko, Wonjae  |e verfasserin  |4 aut 
700 1 |a Lee, Kangjae  |e verfasserin  |4 aut 
700 1 |a Jung, Yoon  |e verfasserin  |4 aut 
700 1 |a Lee, Changha  |e verfasserin  |4 aut 
700 1 |a Lee, Nohyun  |e verfasserin  |4 aut 
700 1 |a Back, Seoin  |e verfasserin  |4 aut 
700 1 |a Choi, Seung Hong  |e verfasserin  |4 aut 
700 1 |a Hyeon, Taeghwan  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 35(2023), 19 vom: 14. Mai, Seite e2207666  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:35  |g year:2023  |g number:19  |g day:14  |g month:05  |g pages:e2207666 
856 4 0 |u http://dx.doi.org/10.1002/adma.202207666  |3 Volltext 
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