Geometric Tuning of Single-Atom FeN4 Sites via Edge-Generation Enhances Multi-Enzymatic Properties

Geometric Tuning of Single-Atom FeN4 Sites via Edge-Generation Enhances Multi-Enzymatic Properties

© 2023 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 19 vom: 14. Mai, Seite e2207666
1. Verfasser: Kim, Kang (VerfasserIn)
Weitere Verfasser: Lee, Jaewoo, Park, Ok Kyu, Kim, Jongseung, Kim, Jiheon, Lee, Donghyun, Paidi, Vinod K, Jung, Euiyeon, Lee, Hyeon Seok, Lee, Bowon, Lee, Chan Woo, Ko, Wonjae, Lee, Kangjae, Jung, Yoon, Lee, Changha, Lee, Nohyun, Back, Seoin, Choi, Seung Hong, Hyeon, Taeghwan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article catalytic tumor therapy edge-generation peroxidase-like activity single-atom nanozymes structure-activity relationship Coloring Agents Peroxidase EC 1.11.1.7 Peroxidases EC 1.11.1.-
Beschreibung
Zusammenfassung:© 2023 Wiley-VCH GmbH.
Single-atom nanozymes (SAzymes) are considered promising alternatives to natural enzymes. The catalytic performance of SAzymes featuring homogeneous, well-defined active structures can be enhanced through elucidating structure-activity relationship and tailoring physicochemical properties. However, manipulating enzymatic properties through structural variation is an underdeveloped approach. Herein, the synthesis of edge-rich Fe single-atom nanozymes (FeNC-edge) via an H2 O2 -mediated edge generation is reported. By controlling the number of edge sites, the peroxidase (POD)- and oxidase (OXD)-like performance is significantly enhanced. The activity enhancement results from the presence of abundant edges, which provide new anchoring sites to mononuclear Fe. Experimental results combined with density functional theory (DFT) calculations reveal that FeN4 moieties in the edge sites display high electron density of Fe atoms and open N atoms. Finally, it is demonstrated that FeNC-edge nanozyme effectively inhibits tumor growth both in vitro and in vivo, suggesting that edge-tailoring is an efficient strategy for developing artificial enzymes as novel catalytic therapeutics
Beschreibung:Date Completed 12.05.2023
Date Revised 12.05.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202207666