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20231226055051.0 |
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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2023.109262
|2 doi
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|a pubmed24n1176.xml
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|a (DE-627)NLM353029564
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|a (NLM)36796470
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|a (PII)S1521-6616(23)00041-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Huang, Ming
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The clinical and immunological characteristics in fatal severe fever with thrombocytopenia syndrome virus (SFTSV) infection
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|c 2023
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 14.03.2023
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|a Date Revised 12.08.2023
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|a published: Print-Electronic
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|a ErratumIn: Clin Immunol. 2023 Oct;255:109715. - PMID 37573228
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|a Citation Status MEDLINE
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|a Copyright © 2023. Published by Elsevier Inc.
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|a OBJECTIVE: This study aimed to make a comprehensive evaluation of peripheral immune profiles for further understanding the immunopathogenesis of severe fever with thrombocytopenia syndrome (SFTS)
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|a METHODS: Forty-seven patients with SFTS virus infection were included, of which 24 were deceased. The percentages, absolute numbers, phenotype of lymphocyte subsets were detected by flow cytometry
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|a RESULTS: In patients with SFTS, the numbers of CD3+T, CD4+T, CD8+T and NKT cells were decreased compared with healthy controls (HCs), accompanied with highly active and exhausted phenotypes for T cells, and overproliferating plasmablasts. High inflammatory status, dysregulation of coagulation and host immune response were more obvious in deceased patients than that of survivors. Higher levels of PCT, IL-6, IL-10, TNF-α, APTT, TT and the occurrence of hemophagocytic lymphohistiocytosis were poor prognostic indicators of SFTS
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| 520 |
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|a CONCLUSIONS: The evaluation of immunological markers in combination with laboratory tests has critical value for selecting prognostic markers and potential treatment target
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|a Journal Article
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|a Hemophagocytic lymphohistiocytosis
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| 650 |
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|a Immunological indicators
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| 650 |
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|a Lymphocyte
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|a Prognosis
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| 650 |
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4 |
|a Severe fever with thrombocytopenia syndrome
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| 700 |
1 |
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|a Wang, Ting
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Shiji
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Guoxing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wei, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Weiyong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hou, Hongyan
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 248(2023) vom: 10. März, Seite 109262
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:248
|g year:2023
|g day:10
|g month:03
|g pages:109262
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2023.109262
|3 Volltext
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|a GBV_ILN_11
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|a GBV_ILN_24
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|a AR
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