The clinical and immunological characteristics in fatal severe fever with thrombocytopenia syndrome virus (SFTSV) infection

The clinical and immunological characteristics in fatal severe fever with thrombocytopenia syndrome virus (SFTSV) infection

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 248(2023) vom: 10. März, Seite 109262
1. Verfasser: Huang, Ming (VerfasserIn)
Weitere Verfasser: Wang, Ting, Huang, Yi, Wang, Yun, Wu, Shiji, Wang, Feng, Tang, Guoxing, Wei, Wei, Liu, Weiyong, Hou, Hongyan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Hemophagocytic lymphohistiocytosis Immunological indicators Lymphocyte Prognosis Severe fever with thrombocytopenia syndrome
Beschreibung
Zusammenfassung:Copyright © 2023. Published by Elsevier Inc.
OBJECTIVE: This study aimed to make a comprehensive evaluation of peripheral immune profiles for further understanding the immunopathogenesis of severe fever with thrombocytopenia syndrome (SFTS)
METHODS: Forty-seven patients with SFTS virus infection were included, of which 24 were deceased. The percentages, absolute numbers, phenotype of lymphocyte subsets were detected by flow cytometry
RESULTS: In patients with SFTS, the numbers of CD3+T, CD4+T, CD8+T and NKT cells were decreased compared with healthy controls (HCs), accompanied with highly active and exhausted phenotypes for T cells, and overproliferating plasmablasts. High inflammatory status, dysregulation of coagulation and host immune response were more obvious in deceased patients than that of survivors. Higher levels of PCT, IL-6, IL-10, TNF-α, APTT, TT and the occurrence of hemophagocytic lymphohistiocytosis were poor prognostic indicators of SFTS
CONCLUSIONS: The evaluation of immunological markers in combination with laboratory tests has critical value for selecting prognostic markers and potential treatment target
Beschreibung:Date Completed 14.03.2023
Date Revised 12.08.2023
published: Print-Electronic
ErratumIn: Clin Immunol. 2023 Oct;255:109715. - PMID 37573228
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2023.109262