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|a 10.1111/nph.18722
|2 doi
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|a pubmed24n1170.xml
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|a eng
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| 100 |
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|a Liu, Dan
|e verfasserin
|4 aut
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|a An elite γ-gliadin allele improves end-use quality in wheat
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 02.06.2023
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|a Date Revised 04.06.2023
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|a published: Print-Electronic
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|a CommentIn: New Phytol. 2023 Jul;239(1):5-6. - PMID 37182221
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|a Citation Status MEDLINE
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|a © 2023 The Authors. New Phytologist © 2023 New Phytologist Foundation.
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|a Gluten is composed of glutenins and gliadins and determines the viscoelastic properties of dough and end-use quality in wheat (Triticum aestivum L.). Gliadins are important for wheat end-use traits, but the contribution of individual gliadin genes is unclear, since gliadins are encoded by a complex, multigenic family, including many pseudogenes. We used CRISPR/Cas9-mediated gene editing and map-based cloning to investigate the contribution of the γ-gliadin genes annotated in the wheat cultivar 'Fielder', showing that Gli-γ1-1D and Gli-γ2-1B account for most of the γ-gliadin accumulation. The impaired activity of only two γ-gliadin genes in knockout mutants improved end-use quality and reduced gluten epitopes associated with celiac disease (CD). Furthermore, we identified an elite haplotype of Gli-γ1-1D linked to higher end-use quality in a wheat germplasm collection and developed a molecular marker for this allele for marker-assisted selection. Our findings provide information and tools for biotechnology-based and classical breeding programs aimed at improving wheat end-use quality
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a celiac disease
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|a end-use quality
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|a gliadin
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|a seed storage protein
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|a wheat
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|a Gliadin
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|a Glutens
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|a 8002-80-0
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| 700 |
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|a Yang, Huaimao
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Zhaoheng
|e verfasserin
|4 aut
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| 700 |
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|a Chen, Qian
|e verfasserin
|4 aut
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|a Guo, Weilong
|e verfasserin
|4 aut
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|a Rossi, Vincenzo
|e verfasserin
|4 aut
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|a Xin, Mingming
|e verfasserin
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|a Du, Jinkun
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|a Hu, Zhaorong
|e verfasserin
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|a Liu, Jie
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|a Peng, Huiru
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|a Ni, Zhongfu
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|a Sun, Qixin
|e verfasserin
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| 700 |
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|a Yao, Yingyin
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 239(2023), 1 vom: 08. Juli, Seite 87-101
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|x 1469-8137
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|g volume:239
|g year:2023
|g number:1
|g day:08
|g month:07
|g pages:87-101
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|u http://dx.doi.org/10.1111/nph.18722
|3 Volltext
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