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231226s2023 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202209497
|2 doi
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|a pubmed24n1167.xml
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|e rakwb
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|a eng
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|a Zhang, Jie
|e verfasserin
|4 aut
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|a Highly Stretchable and Biocompatible Wrinkled Nanoclay-Composite Hydrogel With Enhanced Sensing Capability for Precise Detection of Myocardial Infarction
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|c 2023
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 03.03.2023
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|a Date Revised 03.03.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a It is challenging to balance high biocompability with good mechanical-electrical sensing performance, especially when triggering inflammatory stress response after in vivo implantation. Herein, a bioinspired wrinkle-reinforced adaptive nanoclay-interlocked soft strain-sensor based on a highly stretchable and elastic ionic-conductive hydrogel is reported. This novel nanoclay-composite hydrogel exhibits excellent tensile properties and high sensing capacity with steady and reliable sensing performance due to the structural-mechanical-electrical integrity of the nanoclay crosslinked and nano-reinforced interpenetrating network. The incorporation of amphiphilic ions provides the hydrogel with significant protein resistance, reducing its non-specific adsorption to proteins upon implantation, improving its biosafety as an implanted device, and maintaining the authenticity of the sensing results. Based on the revealed sensing enhanced mechanism based on hierarchical ordered structures as a proof-of-concept application, this hydrogel sensor is demonstrated to be able to accurately localize the region where myocardial infarction occurs and may become a novel strategy for real-time monitoring of pathological changes in heart disease
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|a Journal Article
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|a mechanical-electrical sensing
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|a myocardial infarction
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|a nano-reinforced hydrogels
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|a protein resistance
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|a wrinkles
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|a Hydrogels
|2 NLM
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| 700 |
1 |
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|a Shen, Si
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Rurong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Jianxing
|e verfasserin
|4 aut
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1 |
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|a Pu, Chunyi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Pinger
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Duan, Qixiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a You, Xintong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Chengzhong
|e verfasserin
|4 aut
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| 700 |
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|a Yan, Bing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Xinrui
|e verfasserin
|4 aut
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1 |
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|a Shen, Ziqi
|e verfasserin
|4 aut
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|a Cai, Liu
|e verfasserin
|4 aut
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1 |
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|a Qiu, Xiaozhong
|e verfasserin
|4 aut
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| 700 |
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|a Hou, Honghao
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 35(2023), 9 vom: 17. März, Seite e2209497
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|x 1521-4095
|7 nnns
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|g volume:35
|g year:2023
|g number:9
|g day:17
|g month:03
|g pages:e2209497
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|u http://dx.doi.org/10.1002/adma.202209497
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