Highly Stretchable and Biocompatible Wrinkled Nanoclay-Composite Hydrogel With Enhanced Sensing Capability for Precise Detection of Myocardial Infarction

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 9 vom: 17. März, Seite e2209497
1. Verfasser:	Zhang, Jie (VerfasserIn)
Weitere Verfasser:	Shen, Si, Lin, Rurong, Huang, Jianxing, Pu, Chunyi, Chen, Pinger, Duan, Qixiang, You, Xintong, Xu, Chengzhong, Yan, Bing, Gao, Xinrui, Shen, Ziqi, Cai, Liu, Qiu, Xiaozhong, Hou, Honghao
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2023
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article mechanical-electrical sensing myocardial infarction nano-reinforced hydrogels protein resistance wrinkles Hydrogels

Beschreibung
Zusammenfassung:	© 2023 Wiley-VCH GmbH. It is challenging to balance high biocompability with good mechanical-electrical sensing performance, especially when triggering inflammatory stress response after in vivo implantation. Herein, a bioinspired wrinkle-reinforced adaptive nanoclay-interlocked soft strain-sensor based on a highly stretchable and elastic ionic-conductive hydrogel is reported. This novel nanoclay-composite hydrogel exhibits excellent tensile properties and high sensing capacity with steady and reliable sensing performance due to the structural-mechanical-electrical integrity of the nanoclay crosslinked and nano-reinforced interpenetrating network. The incorporation of amphiphilic ions provides the hydrogel with significant protein resistance, reducing its non-specific adsorption to proteins upon implantation, improving its biosafety as an implanted device, and maintaining the authenticity of the sensing results. Based on the revealed sensing enhanced mechanism based on hierarchical ordered structures as a proof-of-concept application, this hydrogel sensor is demonstrated to be able to accurately localize the region where myocardial infarction occurs and may become a novel strategy for real-time monitoring of pathological changes in heart disease
Beschreibung:	Date Completed 03.03.2023 Date Revised 03.03.2023 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202209497