3D-Bioprinted Phantom with Human Skin Phototypes for Biomedical Optics

3D-Bioprinted Phantom with Human Skin Phototypes for Biomedical Optics

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 3 vom: 01. Jan., Seite e2206385
1. Verfasser: Yim, Wonjun (VerfasserIn)
Weitere Verfasser: Zhou, Jiajing, Sasi, Lekshmi, Zhao, Jiayu, Yeung, Justin, Cheng, Yong, Jin, Zhicheng, Johnson, Wade, Xu, Ming, Palma-Chavez, Jorge, Fu, Lei, Qi, Baiyan, Retout, Maurice, Shah, Nisarg J, Bae, Jinhye, Jokerst, Jesse V
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article 3D bioprinting artificial skins bioinspired materials biophotonic devices Melanins
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520 |a 3D-bioprinted skin-mimicking phantoms with skin colors ranging across the Fitzpatrick scale are reported. These tools can help understand the impact of skin phototypes on biomedical optics. Synthetic melanin nanoparticles of different sizes (70-500 nm) and clusters are fabricated to mimic the optical behavior of melanosome. The absorption coefficient and reduced scattering coefficient of the phantoms are comparable to real human skin. Further the melanin content and distribution in the phantoms versus real human skins are validated via photoacoustic (PA) imaging. The PA signal of the phantom can be improved by: 1) increasing melanin size (3-450-fold), 2) increasing clustering (2-10.5-fold), and 3) increasing concentration (1.3-8-fold). Then, multiple biomedical optics tools (e.g., PA, fluorescence imaging, and photothermal therapy) are used to understand the impact of skin tone on these modalities. These well-defined 3D-bioprinted phantoms may have value in translating biomedical optics and reducing racial bias 
650 4 |a Journal Article 
650 4 |a 3D bioprinting 
650 4 |a artificial skins 
650 4 |a bioinspired materials 
650 4 |a biophotonic devices 
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700 1 |a Zhou, Jiajing  |e verfasserin  |4 aut 
700 1 |a Sasi, Lekshmi  |e verfasserin  |4 aut 
700 1 |a Zhao, Jiayu  |e verfasserin  |4 aut 
700 1 |a Yeung, Justin  |e verfasserin  |4 aut 
700 1 |a Cheng, Yong  |e verfasserin  |4 aut 
700 1 |a Jin, Zhicheng  |e verfasserin  |4 aut 
700 1 |a Johnson, Wade  |e verfasserin  |4 aut 
700 1 |a Xu, Ming  |e verfasserin  |4 aut 
700 1 |a Palma-Chavez, Jorge  |e verfasserin  |4 aut 
700 1 |a Fu, Lei  |e verfasserin  |4 aut 
700 1 |a Qi, Baiyan  |e verfasserin  |4 aut 
700 1 |a Retout, Maurice  |e verfasserin  |4 aut 
700 1 |a Shah, Nisarg J  |e verfasserin  |4 aut 
700 1 |a Bae, Jinhye  |e verfasserin  |4 aut 
700 1 |a Jokerst, Jesse V  |e verfasserin  |4 aut 
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773 1 8 |g volume:35  |g year:2023  |g number:3  |g day:01  |g month:01  |g pages:e2206385 
856 4 0 |u http://dx.doi.org/10.1002/adma.202206385  |3 Volltext 
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