3D-Bioprinted Phantom with Human Skin Phototypes for Biomedical Optics

3D-Bioprinted Phantom with Human Skin Phototypes for Biomedical Optics

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 3 vom: 01. Jan., Seite e2206385
1. Verfasser: Yim, Wonjun (VerfasserIn)
Weitere Verfasser: Zhou, Jiajing, Sasi, Lekshmi, Zhao, Jiayu, Yeung, Justin, Cheng, Yong, Jin, Zhicheng, Johnson, Wade, Xu, Ming, Palma-Chavez, Jorge, Fu, Lei, Qi, Baiyan, Retout, Maurice, Shah, Nisarg J, Bae, Jinhye, Jokerst, Jesse V
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article 3D bioprinting artificial skins bioinspired materials biophotonic devices Melanins
Beschreibung
Zusammenfassung:© 2022 Wiley-VCH GmbH.
3D-bioprinted skin-mimicking phantoms with skin colors ranging across the Fitzpatrick scale are reported. These tools can help understand the impact of skin phototypes on biomedical optics. Synthetic melanin nanoparticles of different sizes (70-500 nm) and clusters are fabricated to mimic the optical behavior of melanosome. The absorption coefficient and reduced scattering coefficient of the phantoms are comparable to real human skin. Further the melanin content and distribution in the phantoms versus real human skins are validated via photoacoustic (PA) imaging. The PA signal of the phantom can be improved by: 1) increasing melanin size (3-450-fold), 2) increasing clustering (2-10.5-fold), and 3) increasing concentration (1.3-8-fold). Then, multiple biomedical optics tools (e.g., PA, fluorescence imaging, and photothermal therapy) are used to understand the impact of skin tone on these modalities. These well-defined 3D-bioprinted phantoms may have value in translating biomedical optics and reducing racial bias
Beschreibung:Date Completed 23.01.2023
Date Revised 02.01.2024
published: Print-Electronic
ErratumIn: Adv Mater. 2023 Jul;35(30):e2305227. - PMID 37497560
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202206385