A Janus Au-Polymersome Heterostructure with Near-Field Enhancement Effect for Implant-Associated Infection Phototherapy

A Janus Au-Polymersome Heterostructure with Near-Field Enhancement Effect for Implant-Associated Infection Phototherapy

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 3 vom: 19. Jan., Seite e2207950
1. Verfasser: Chen, Chuanshuang (VerfasserIn)
Weitere Verfasser: Chu, Guangyu, He, Wanting, Liu, Yannan, Dai, Kai, Valdez, Jesus, Moores, Audrey, Huang, Pei, Wang, Zhaohong, Jin, Jiale, Guan, Ming, Jiang, Wenfeng, Mai, Yiyong, Ma, Dongling, Wang, Yue, Zhou, Yongfeng
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2023
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Janus particles antibacterial properties photodynamic therapy photothermal therapy polymersomes Gold 7440-57-5 Polymers
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520 |a Polymer-inorganic hybrid Janus nanoparticles (PI-JNPs) have attracted extensive attention due to their special structures and functions. However, achieving the synergistic enhancement of photochemical activity between polymer and inorganic moieties in PI-JNPs remains challenging. Herein, the construction of a novel Janus Au-porphyrin polymersome (J-AuPPS) heterostructure by a facile one-step photocatalytic synthesis is reported. The near-field enhancement (NFE) effect between porphyrin polymersome (PPS) and Au nanoparticles in J-AuPPS is achieved to enhance its near-infrared (NIR) light absorption and electric/thermal field intensity at their interface, which improves the energy transfer and energetic charge-carrier generation. Therefore, J-AuPPS shows a higher NIR-activated photothermal conversion efficiency (48.4%) and generates more singlet oxygen compared with non-Janus core-particle Au-PPS nanostructure (28.4%). As a result, J-AuPPS exhibits excellent dual-mode (photothermal/photodynamic) antibacterial and anti-biofilm performance, thereby significantly enhancing the in vivo therapeutic effect in an implant-associated-infection rat model. This work is believed to motivate the rational design of advanced hybrid JNPs with desirable NFE effect and further extend their biological applications 
650 4 |a Journal Article 
650 4 |a Janus particles 
650 4 |a antibacterial properties 
650 4 |a photodynamic therapy 
650 4 |a photothermal therapy 
650 4 |a polymersomes 
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650 7 |a 7440-57-5  |2 NLM 
650 7 |a Polymers  |2 NLM 
700 1 |a Chu, Guangyu  |e verfasserin  |4 aut 
700 1 |a He, Wanting  |e verfasserin  |4 aut 
700 1 |a Liu, Yannan  |e verfasserin  |4 aut 
700 1 |a Dai, Kai  |e verfasserin  |4 aut 
700 1 |a Valdez, Jesus  |e verfasserin  |4 aut 
700 1 |a Moores, Audrey  |e verfasserin  |4 aut 
700 1 |a Huang, Pei  |e verfasserin  |4 aut 
700 1 |a Wang, Zhaohong  |e verfasserin  |4 aut 
700 1 |a Jin, Jiale  |e verfasserin  |4 aut 
700 1 |a Guan, Ming  |e verfasserin  |4 aut 
700 1 |a Jiang, Wenfeng  |e verfasserin  |4 aut 
700 1 |a Mai, Yiyong  |e verfasserin  |4 aut 
700 1 |a Ma, Dongling  |e verfasserin  |4 aut 
700 1 |a Wang, Yue  |e verfasserin  |4 aut 
700 1 |a Zhou, Yongfeng  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 35(2023), 3 vom: 19. Jan., Seite e2207950  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:35  |g year:2023  |g number:3  |g day:19  |g month:01  |g pages:e2207950 
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