A Janus Au-Polymersome Heterostructure with Near-Field Enhancement Effect for Implant-Associated Infection Phototherapy

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 35(2023), 3 vom: 19. Jan., Seite e2207950
1. Verfasser:	Chen, Chuanshuang (VerfasserIn)
Weitere Verfasser:	Chu, Guangyu, He, Wanting, Liu, Yannan, Dai, Kai, Valdez, Jesus, Moores, Audrey, Huang, Pei, Wang, Zhaohong, Jin, Jiale, Guan, Ming, Jiang, Wenfeng, Mai, Yiyong, Ma, Dongling, Wang, Yue, Zhou, Yongfeng
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2023
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article Janus particles antibacterial properties photodynamic therapy photothermal therapy polymersomes Gold 7440-57-5 Polymers

Beschreibung
Zusammenfassung:	© 2022 Wiley-VCH GmbH. Polymer-inorganic hybrid Janus nanoparticles (PI-JNPs) have attracted extensive attention due to their special structures and functions. However, achieving the synergistic enhancement of photochemical activity between polymer and inorganic moieties in PI-JNPs remains challenging. Herein, the construction of a novel Janus Au-porphyrin polymersome (J-AuPPS) heterostructure by a facile one-step photocatalytic synthesis is reported. The near-field enhancement (NFE) effect between porphyrin polymersome (PPS) and Au nanoparticles in J-AuPPS is achieved to enhance its near-infrared (NIR) light absorption and electric/thermal field intensity at their interface, which improves the energy transfer and energetic charge-carrier generation. Therefore, J-AuPPS shows a higher NIR-activated photothermal conversion efficiency (48.4%) and generates more singlet oxygen compared with non-Janus core-particle Au-PPS nanostructure (28.4%). As a result, J-AuPPS exhibits excellent dual-mode (photothermal/photodynamic) antibacterial and anti-biofilm performance, thereby significantly enhancing the in vivo therapeutic effect in an implant-associated-infection rat model. This work is believed to motivate the rational design of advanced hybrid JNPs with desirable NFE effect and further extend their biological applications
Beschreibung:	Date Completed 23.01.2023 Date Revised 23.01.2023 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202207950