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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1111/nph.18414
|2 doi
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|a pubmed24n1149.xml
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|a (DE-627)NLM344954323
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|a (NLM)35976797
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Prasad, Melvin
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Double DJ-1 domain containing Arabidopsis DJ-1D is a robust macromolecule deglycase
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| 264 |
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1 |
|c 2022
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 07.10.2022
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|a Date Revised 08.11.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation.
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|a Plants, being sessile, are prone to genotoxin-induced macromolecule damage. Among the inevitable damaging agents are reactive carbonyls that induce glycation of DNA, RNA and proteins to result in the build-up of advanced glycated end-products. However, it is unclear how plants repair glycated macromolecules. DJ-1/PARK7 members are a highly conserved family of moonlighting proteins having double domains in higher plants and single domains in other phyla. Here we show that Arabidopsis DJ-1D offers robust tolerance to endogenous and exogenous stresses through its ability to repair glycated DNA, RNA and proteins. DJ-1D also reduced the formation of reactive carbonyls through its efficient methylglyoxalase activity. Strikingly, full-length double domain-containing DJ-1D suppressed the formation of advanced glycated end-products in yeast and plants. DJ-1D also efficiently repaired glycated nucleic acids and nucleotides in vitro and mitochondrial DNA in vivo under stress, indicating the existence of a new DNA repair pathway in plants. We propose that multi-stress responding plant DJ-1 members, often present in multiple copies among plants, probably contributed to the adaptation to a variety of endogenous and exogenous stresses
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4 |
|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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4 |
|a Arabidopsis thaliana
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|a DJ-1 family proteins
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4 |
|a DNA repair
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4 |
|a advanced glycation end-products
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| 650 |
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4 |
|a glycation
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4 |
|a methylglyoxal
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| 650 |
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4 |
|a reactive carbonyls
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| 650 |
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4 |
|a stress responses
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| 650 |
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7 |
|a DNA, Mitochondrial
|2 NLM
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| 650 |
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7 |
|a Mutagens
|2 NLM
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| 650 |
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7 |
|a Nucleic Acids
|2 NLM
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| 650 |
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7 |
|a Nucleotides
|2 NLM
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| 650 |
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7 |
|a RNA
|2 NLM
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| 650 |
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7 |
|a 63231-63-0
|2 NLM
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| 650 |
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|a Lactoylglutathione Lyase
|2 NLM
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| 650 |
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7 |
|a EC 4.4.1.5
|2 NLM
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| 700 |
1 |
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|a Kataria, Priyanka
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ningaraju, Sunayana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Buddidathi, Radhika
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bankapalli, Kondalarao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Swetha, Chenna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Susarla, Gautam
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Venkatesan, Radhika
|e verfasserin
|4 aut
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| 700 |
1 |
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|a D'Silva, Patrick
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shivaprasad, Padubidri V
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 236(2022), 3 vom: 02. Nov., Seite 1061-1074
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:236
|g year:2022
|g number:3
|g day:02
|g month:11
|g pages:1061-1074
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| 856 |
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|u http://dx.doi.org/10.1111/nph.18414
|3 Volltext
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 236
|j 2022
|e 3
|b 02
|c 11
|h 1061-1074
|