Double DJ-1 domain containing Arabidopsis DJ-1D is a robust macromolecule deglycase

Double DJ-1 domain containing Arabidopsis DJ-1D is a robust macromolecule deglycase

© 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 236(2022), 3 vom: 02. Nov., Seite 1061-1074
1. Verfasser: Prasad, Melvin (VerfasserIn)
Weitere Verfasser: Kataria, Priyanka, Ningaraju, Sunayana, Buddidathi, Radhika, Bankapalli, Kondalarao, Swetha, Chenna, Susarla, Gautam, Venkatesan, Radhika, D'Silva, Patrick, Shivaprasad, Padubidri V
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Arabidopsis thaliana DJ-1 family proteins DNA repair advanced glycation end-products glycation methylglyoxal reactive carbonyls stress responses mehr... DNA, Mitochondrial Mutagens Nucleic Acids Nucleotides RNA 63231-63-0 Lactoylglutathione Lyase EC 4.4.1.5
Beschreibung
Zusammenfassung:© 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation.
Plants, being sessile, are prone to genotoxin-induced macromolecule damage. Among the inevitable damaging agents are reactive carbonyls that induce glycation of DNA, RNA and proteins to result in the build-up of advanced glycated end-products. However, it is unclear how plants repair glycated macromolecules. DJ-1/PARK7 members are a highly conserved family of moonlighting proteins having double domains in higher plants and single domains in other phyla. Here we show that Arabidopsis DJ-1D offers robust tolerance to endogenous and exogenous stresses through its ability to repair glycated DNA, RNA and proteins. DJ-1D also reduced the formation of reactive carbonyls through its efficient methylglyoxalase activity. Strikingly, full-length double domain-containing DJ-1D suppressed the formation of advanced glycated end-products in yeast and plants. DJ-1D also efficiently repaired glycated nucleic acids and nucleotides in vitro and mitochondrial DNA in vivo under stress, indicating the existence of a new DNA repair pathway in plants. We propose that multi-stress responding plant DJ-1 members, often present in multiple copies among plants, probably contributed to the adaptation to a variety of endogenous and exogenous stresses
Beschreibung:Date Completed 07.10.2022
Date Revised 08.11.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1469-8137
DOI:10.1111/nph.18414