Integration of multi-omics data reveals interplay between brassinosteroid and Target of Rapamycin Complex signaling in Arabidopsis

Integration of multi-omics data reveals interplay between brassinosteroid and Target of Rapamycin Complex signaling in Arabidopsis

© 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 236(2022), 3 vom: 08. Nov., Seite 893-910
1. Verfasser: Montes, Christian (VerfasserIn)
Weitere Verfasser: Wang, Ping, Liao, Ching-Yi, Nolan, Trevor M, Song, Gaoyuan, Clark, Natalie M, Elmore, J Mitch, Guo, Hongqing, Bassham, Diane C, Yin, Yanhai, Walley, Justin W
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't BIN2 RAP TOR TORAutophagy brassinosteroids integrative mehr... multi-omics network Arabidopsis Proteins Brassinosteroids Transcription Factors Protein Kinases EC 2.7.- BIN2 protein, Arabidopsis EC 2.7.1.- Sirolimus W36ZG6FT64
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520 |a © 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation. 
520 |a Brassinosteroids (BRs) and Target of Rapamycin Complex (TORC) are two major actors coordinating plant growth and stress responses. Brassinosteroids function through a signaling pathway to extensively regulate gene expression and TORC is known to regulate translation and autophagy. Recent studies have revealed connections between these two pathways, but a system-wide view of their interplay is still missing. We quantified the level of 23 975 transcripts, 11 183 proteins, and 27 887 phosphorylation sites in wild-type Arabidopsis thaliana and in mutants with altered levels of either BRASSINOSTEROID INSENSITIVE 2 (BIN2) or REGULATORY ASSOCIATED PROTEIN OF TOR 1B (RAPTOR1B), two key players in BR and TORC signaling, respectively. We found that perturbation of BIN2 or RAPTOR1B levels affects a common set of gene-products involved in growth and stress responses. Furthermore, we used the multi-omic data to reconstruct an integrated signaling network. We screened 41 candidate genes identified from the reconstructed network and found that loss of function mutants of many of these proteins led to an altered BR response and/or modulated autophagy activity. Altogether, these results establish a predictive network that defines different layers of molecular interactions between BR- or TORC-regulated growth and autophagy 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, U.S. Gov't, Non-P.H.S. 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a BIN2 
650 4 |a RAP 
650 4 |a TOR 
650 4 |a TORAutophagy 
650 4 |a brassinosteroids 
650 4 |a integrative 
650 4 |a multi-omics 
650 4 |a network 
650 7 |a Arabidopsis Proteins  |2 NLM 
650 7 |a Brassinosteroids  |2 NLM 
650 7 |a Transcription Factors  |2 NLM 
650 7 |a Protein Kinases  |2 NLM 
650 7 |a EC 2.7.-  |2 NLM 
650 7 |a BIN2 protein, Arabidopsis  |2 NLM 
650 7 |a EC 2.7.1.-  |2 NLM 
650 7 |a Sirolimus  |2 NLM 
650 7 |a W36ZG6FT64  |2 NLM 
700 1 |a Wang, Ping  |e verfasserin  |4 aut 
700 1 |a Liao, Ching-Yi  |e verfasserin  |4 aut 
700 1 |a Nolan, Trevor M  |e verfasserin  |4 aut 
700 1 |a Song, Gaoyuan  |e verfasserin  |4 aut 
700 1 |a Clark, Natalie M  |e verfasserin  |4 aut 
700 1 |a Elmore, J Mitch  |e verfasserin  |4 aut 
700 1 |a Guo, Hongqing  |e verfasserin  |4 aut 
700 1 |a Bassham, Diane C  |e verfasserin  |4 aut 
700 1 |a Yin, Yanhai  |e verfasserin  |4 aut 
700 1 |a Walley, Justin W  |e verfasserin  |4 aut 
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773 1 8 |g volume:236  |g year:2022  |g number:3  |g day:08  |g month:11  |g pages:893-910 
856 4 0 |u http://dx.doi.org/10.1111/nph.18404  |3 Volltext 
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