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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202202057
|2 doi
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|a pubmed24n1143.xml
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|a (DE-627)NLM343133369
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|a (NLM)35792703
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Chen, Wen
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Toward Tissue-Like Material Properties
|b Inducing In Situ Adaptive Behavior in Fibrous Hydrogels
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 16.09.2022
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|a Date Revised 16.09.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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|a The materials properties of biological tissues are unique. Nature is able to spatially and temporally manipulate (mechanical) properties while maintaining responsiveness toward a variety of cues; all without majorly changing the material's composition. Artificial mimics, synthetic or biomaterial-based are far less advanced and poorly reproduce the natural cell microenvironment. A viable strategy to generate materials with advanced properties combines different materials into nanocomposites. This work describes nanocomposites of a synthetic fibrous hydrogel, based on polyisocyanide (PIC), that is noncovalently linked to a responsive cross-linker. The introduction of the cross-linker transforms the PIC gel from a static fibrous extracellular matrix mimic to a highly dynamic material that maintains biocompatibility, as demonstrated by in situ modification of the (non)linear mechanical properties and efficient self-healing properties. Key in the material design is cross-linking at the fibrillar level using nanoparticles, which, simultaneously may be used to introduce more advanced properties
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|a Journal Article
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|a adaptive behavior
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|a biomimetic hydrogels
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|a multiresponsiveness
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4 |
|a polyisocyanides
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4 |
|a self-healing behavior
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|a Biocompatible Materials
|2 NLM
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|a Hydrogels
|2 NLM
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| 700 |
1 |
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|a Kumari, Jyoti
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yuan, Hongbo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Fan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kouwer, Paul H J
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 37 vom: 10. Sept., Seite e2202057
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:34
|g year:2022
|g number:37
|g day:10
|g month:09
|g pages:e2202057
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|u http://dx.doi.org/10.1002/adma.202202057
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