Toward Tissue-Like Material Properties : Inducing In Situ Adaptive Behavior in Fibrous Hydrogels

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 37 vom: 10. Sept., Seite e2202057
1. Verfasser:	Chen, Wen (VerfasserIn)
Weitere Verfasser:	Kumari, Jyoti, Yuan, Hongbo, Yang, Fan, Kouwer, Paul H J
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2022
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article adaptive behavior biomimetic hydrogels multiresponsiveness polyisocyanides self-healing behavior Biocompatible Materials Hydrogels

Beschreibung
Zusammenfassung:	© 2022 The Authors. Advanced Materials published by Wiley-VCH GmbH. The materials properties of biological tissues are unique. Nature is able to spatially and temporally manipulate (mechanical) properties while maintaining responsiveness toward a variety of cues; all without majorly changing the material's composition. Artificial mimics, synthetic or biomaterial-based are far less advanced and poorly reproduce the natural cell microenvironment. A viable strategy to generate materials with advanced properties combines different materials into nanocomposites. This work describes nanocomposites of a synthetic fibrous hydrogel, based on polyisocyanide (PIC), that is noncovalently linked to a responsive cross-linker. The introduction of the cross-linker transforms the PIC gel from a static fibrous extracellular matrix mimic to a highly dynamic material that maintains biocompatibility, as demonstrated by in situ modification of the (non)linear mechanical properties and efficient self-healing properties. Key in the material design is cross-linking at the fibrillar level using nanoparticles, which, simultaneously may be used to introduce more advanced properties
Beschreibung:	Date Completed 16.09.2022 Date Revised 16.09.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202202057