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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1111/cobi.13940
|2 doi
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|a pubmed25n1139.xml
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|a (DE-627)NLM341958913
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|a DE-627
|b ger
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|e rakwb
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|a eng
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| 100 |
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|a Nabutanyi, Peter
|e verfasserin
|4 aut
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|a Modeling minimum viable population size with multiple genetic problems of small populations
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 03.10.2022
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|a Date Revised 26.12.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 The Authors. Conservation Biology published by Wiley Periodicals LLC on behalf of Society for Conservation Biology.
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|a An important goal for conservation is to define minimum viable population (MVP) sizes for long-term persistence of a species. There is increasing evidence of the role of genetics in population extinction; thus, conservation practitioners are starting to consider the effects of deleterious mutations (DM), in particular the effects of inbreeding depression on fitness. We sought to develop methods to account for genetic problems other than inbreeding depression in MVP estimates, quantify the effect of the interaction of multiple genetic problems on MVP sizes, and find ways to reduce the arbitrariness of time and persistence probability thresholds in MVP analyses. To do so, we developed ecoevolutionary quantitative models to track population size and levels of genetic diversity. We assumed a biallelic multilocus genome with loci under single or multiple, interacting genetic forces. We included mutation-selection-drift balance (for loci with DM) and 3 forms of balancing selection for loci for which variation is lost through genetic drift. We defined MVP size as the lowest population size that avoids an ecoevolutionary extinction vortex. For populations affected by only balancing selection, MVP size decreased rapidly as mutation rates increased. For populations affected by mutation-selection-drift balance, the MVP size increased rapidly. In addition, MVP sizes increased rapidly as the number of loci increased under the same or different selection mechanisms until even arbitrarily large populations could not survive. In the case of fixed number of loci under selection, interaction of genetic problems did not always increase MVP sizes. To further enhance understanding about interaction of genetic problems, there is need for more empirical studies to reveal how different genetic processes interact in the genome
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a acumulación de mutaciones
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| 650 |
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4 |
|a balancing selection
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| 650 |
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|a depresión endogámica
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| 650 |
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4 |
|a diversidad genética
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| 650 |
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4 |
|a extinction vortex
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| 650 |
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|a genetic diversity
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| 650 |
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4 |
|a inbreeding depression
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| 650 |
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|a mutation accumulation
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| 650 |
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|a selección estabilizadora
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| 650 |
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|a vórtice de extinción
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| 650 |
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|a 平衡选择
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| 650 |
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|a 灭绝漩涡
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|a 突变积累
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| 650 |
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|a 近交衰退
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| 650 |
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|a 遗传多样性
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1 |
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|a Wittmann, Meike J
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Conservation biology : the journal of the Society for Conservation Biology
|d 1989
|g 36(2022), 5 vom: 01. Okt., Seite e13940
|w (DE-627)NLM098176803
|x 1523-1739
|7 nnas
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| 773 |
1 |
8 |
|g volume:36
|g year:2022
|g number:5
|g day:01
|g month:10
|g pages:e13940
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|u http://dx.doi.org/10.1111/cobi.13940
|3 Volltext
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