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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1107/S1600577522001874
|2 doi
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|a pubmed25n1134.xml
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|a (NLM)35511013
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Sala, Simone
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Dose-efficient multimodal microscopy of human tissue at a hard X-ray nanoprobe beamline
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 09.05.2022
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|a Date Revised 27.08.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a open access.
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|a X-ray fluorescence microscopy performed at nanofocusing synchrotron beamlines produces quantitative elemental distribution maps at unprecedented resolution (down to a few tens of nanometres), at the expense of relatively long measuring times and high absorbed doses. In this work, a method was implemented in which fast low-dose in-line holography was used to produce quantitative electron density maps at the mesoscale prior to nanoscale X-ray fluorescence acquisition. These maps ensure more efficient fluorescence scans and the reduction of the total absorbed dose, often relevant for radiation-sensitive (e.g. biological) samples. This multimodal microscopy approach was demonstrated on human sural nerve tissue. The two imaging modes provide complementary information at a comparable resolution, ultimately limited by the focal spot size. The experimental setup presented allows the user to swap between them in a flexible and reproducible fashion, as well as to easily adapt the scanning parameters during an experiment to fine-tune resolution and field of view
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|a Journal Article
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|a X-ray fluorescence emission spectroscopy
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|a X-ray microscopy
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|a in-line holography
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|a Zhang, Yuhe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a De La Rosa, Nathaly
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dreier, Till
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kahnt, Maik
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Langer, Max
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dahlin, Lars B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bech, Martin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Villanueva-Perez, Pablo
|e verfasserin
|4 aut
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| 700 |
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|a Kalbfleisch, Sebastian
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 29(2022), Pt 3 vom: 01. Mai, Seite 807-815
|w (DE-627)NLM09824129X
|x 1600-5775
|7 nnas
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| 773 |
1 |
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|g volume:29
|g year:2022
|g number:Pt 3
|g day:01
|g month:05
|g pages:807-815
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|u http://dx.doi.org/10.1107/S1600577522001874
|3 Volltext
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