|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM340396547 |
| 003 |
DE-627 |
| 005 |
20240827232100.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231226s2022 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1107/S1600577522001874
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1514.xml
|
| 035 |
|
|
|a (DE-627)NLM340396547
|
| 035 |
|
|
|a (NLM)35511013
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Sala, Simone
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Dose-efficient multimodal microscopy of human tissue at a hard X-ray nanoprobe beamline
|
| 264 |
|
1 |
|c 2022
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 09.05.2022
|
| 500 |
|
|
|a Date Revised 27.08.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a open access.
|
| 520 |
|
|
|a X-ray fluorescence microscopy performed at nanofocusing synchrotron beamlines produces quantitative elemental distribution maps at unprecedented resolution (down to a few tens of nanometres), at the expense of relatively long measuring times and high absorbed doses. In this work, a method was implemented in which fast low-dose in-line holography was used to produce quantitative electron density maps at the mesoscale prior to nanoscale X-ray fluorescence acquisition. These maps ensure more efficient fluorescence scans and the reduction of the total absorbed dose, often relevant for radiation-sensitive (e.g. biological) samples. This multimodal microscopy approach was demonstrated on human sural nerve tissue. The two imaging modes provide complementary information at a comparable resolution, ultimately limited by the focal spot size. The experimental setup presented allows the user to swap between them in a flexible and reproducible fashion, as well as to easily adapt the scanning parameters during an experiment to fine-tune resolution and field of view
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a X-ray fluorescence emission spectroscopy
|
| 650 |
|
4 |
|a X-ray microscopy
|
| 650 |
|
4 |
|a in-line holography
|
| 700 |
1 |
|
|a Zhang, Yuhe
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a De La Rosa, Nathaly
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Dreier, Till
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kahnt, Maik
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Langer, Max
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Dahlin, Lars B
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Bech, Martin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Villanueva-Perez, Pablo
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kalbfleisch, Sebastian
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Journal of synchrotron radiation
|d 1994
|g 29(2022), Pt 3 vom: 01. Mai, Seite 807-815
|w (DE-627)NLM09824129X
|x 1600-5775
|7 nnns
|
| 773 |
1 |
8 |
|g volume:29
|g year:2022
|g number:Pt 3
|g day:01
|g month:05
|g pages:807-815
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1107/S1600577522001874
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_40
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_2005
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 29
|j 2022
|e Pt 3
|b 01
|c 05
|h 807-815
|