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231226s2022 xx |||||o 00| ||eng c |
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|a 10.1111/nph.18185
|2 doi
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|a pubmed25n1133.xml
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|a (DE-627)NLM340147881
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|a (NLM)35485957
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Attri, Komal
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Rapid sequence and functional diversification of a miRNA superfamily targeting calcium signaling components in seed plants
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| 264 |
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1 |
|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 01.07.2022
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|a Date Revised 31.07.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 The Authors. New Phytologist © 2022 New Phytologist Foundation.
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|a MicroRNA (miRNA)-directed posttranscriptional gene silencing (miR-PTGS) is an integral component of gene regulatory networks governing plant development and responses to the environment. The sequence homology between Sly-miR4376, a miRNA common to Solanaceae and reported to target autoinhibited Ca2+ -ATPase 10 (ACA10) messenger RNA (mRNA) in tomato, and Arabidopsis miR391 (Ath-miR391), previously annotated as a nonconserved member of the deeply conserved miR390 family, has prompted us to revisit the function of Ath-miR391, as well as its regulatory conservation. A combination of genetic, molecular, and bioinformatic analyses revealed a hidden conservation for miR-PTGS of ACA10 homologs in spermatophytes. We found that the Arabidopsis ACA10 mRNA undergoes miR391-directed cleavage in vivo. Furthermore, transgenic overexpression of miR391 recapitulated the compact inflorescence (cif) phenotypes characteristic of ACA10 loss-of-function mutants, due to miR391-directed PTGS of ACA10. Significantly, comprehensive data mining revealed robust evidence for widespread PTGS of ACA10 homologs directed by a superfamily of related miRNAs sharing a conserved sequence core. Intriguingly, the ACA-targeting miRNAs in Poaceae also direct PTGS for calmodulin-like proteins which are putative Ca2+ sensors. The PTGS of ACA10 homologs is therefore directed by a miRNA superfamily that is of ancient origin and has undergone rapid sequence diversification associated with functional innovation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Arabidopsis
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| 650 |
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|a EF hand (EF-h)
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| 650 |
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|a autoinhibited Ca2+-ATPase (ACA)
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| 650 |
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|a calcium signaling
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| 650 |
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|a calmodulin-like (CML)
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| 650 |
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|a miR391
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| 650 |
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|a posttranscriptional gene silencing (PTGS)
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| 650 |
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|a spermatophytes
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| 650 |
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|a Arabidopsis Proteins
|2 NLM
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| 650 |
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|a MicroRNAs
|2 NLM
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| 650 |
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|a RNA, Messenger
|2 NLM
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| 700 |
1 |
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|a Zhang, Zijie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Singh, Atinder
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sharrock, Robert A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Zhixin
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 235(2022), 3 vom: 11. Aug., Seite 1082-1095
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnas
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| 773 |
1 |
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|g volume:235
|g year:2022
|g number:3
|g day:11
|g month:08
|g pages:1082-1095
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| 856 |
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|u http://dx.doi.org/10.1111/nph.18185
|3 Volltext
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|d 235
|j 2022
|e 3
|b 11
|c 08
|h 1082-1095
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