Conjugated Oligoelectrolytes for Long-Term Tumor Tracking with Incremental NIR-II Emission

Conjugated Oligoelectrolytes for Long-Term Tumor Tracking with Incremental NIR-II Emission

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 20 vom: 21. Mai, Seite e2201989
1. Verfasser: Zhou, Cheng (VerfasserIn)
Weitere Verfasser: Li, Zeshun, Zhu, Ziyue, Chia, Geraldine W N, Mikhailovsky, Alexander, Vázquez, Ricardo Javier, Chan, Samuel J W, Li, Kai, Liu, Bin, Bazan, Guillermo C
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article NIR-II window conjugated oligoelectrolytes fluorogenic materials tumor tracking Water 059QF0KO0R
Beschreibung
Zusammenfassung:© 2022 Wiley-VCH GmbH.
The design and synthesis of the near-infrared (NIR)-II emissive conjugated oligoelectrolyte COE-BBT are reported. COE-BBT has a solubility in aqueous media greater than 50 mg mL-1 , low toxicity, and a propensity to intercalate lipid bilayers, wherein it exhibits a higher emission quantum yield relative to aqueous media. Addition of COE-BBT to cells provides two emission channels, at ≈500 and ≈1020 nm, depending on the excitation wavelength, which facilitates in vitro confocal microscopy and in vivo animal imaging. The NIR-II emission of COE-BBT is used to track intracranial and subcutaneous tumor progression in mice. Of relevance is that the total NIR-II intensity increases over time. This phenomenon is attributed to a progressive attenuation of a COE-BBT self-quenching effect within the cells due to the expected dye dilution per cell as the tumor proliferates
Beschreibung:Date Completed 23.05.2022
Date Revised 23.05.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.202201989