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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202110690
|2 doi
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|a pubmed25n1126.xml
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|a eng
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|a Zhang, Junfeng
|e verfasserin
|4 aut
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|a A Multifunctional Photoacoustic/Fluorescence Dual-Mode-Imaging Gold-Based Theranostic Nanoformulation without External Laser Limitations
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|c 2022
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 16.05.2022
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|a Date Revised 16.05.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Theranostics is a new type of biomedical technology that organically combines the diagnosis and therapy of diseases. Among molecular imaging techniques, the integration of photoacoustic (PA) and fluorescence (FL) imaging modes with high sensitivity and imaging depth provides precise diagnostic outcomes. Gold nanorods (Au NRs) are well-known contrast agents for PA imaging and photothermal therapy. However, their high toxicity, poor biocompatibility, rapid clearance, and the need for an external laser source limit their application. Therefore, modification of Au NRs with carbon-based nanomaterials (CBNs) is done to obtain a multifunctional dual-mode gold-based nanoformulation (mdGC), which preforms dual-mode imaging of PA and FL. The results show that mdGC promotes tumor cell apoptosis and exhibits good antitumor performance through the mitochondria-mediated apoptotic pathway by increasing the production of intracellular reactive oxygen species, reducing mitochondrial membrane potential, and regulating the expression of apoptosis-related genes. The targeting rate of mdGC to tumor tissue is up to 20.71 ± 1.94% ID g-1 ; the tumor growth inhibition rate is as high as 80.44% without external laser sources. In general, mdGC is a potential multifunctional diagnostic and therapy integrated nanoformulation
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|a Journal Article
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|a gold nanorods
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|a mitochondria-mediated apoptosis
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|a photoacoustic and fluorescence imaging
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|a reactive oxygen species
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|a theranostic nanoformulation
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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|a Yin, Xiaofeng
|e verfasserin
|4 aut
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|a Li, Chenchen
|e verfasserin
|4 aut
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|a Yin, Xuelian
|e verfasserin
|4 aut
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|a Xue, Qianghua
|e verfasserin
|4 aut
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|a Ding, Lin
|e verfasserin
|4 aut
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|a Ju, Jiale
|e verfasserin
|4 aut
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|a Ma, Jifei
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|4 aut
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|a Zhu, Ying
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|a Du, Dongshu
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|a Reis, Rui L
|e verfasserin
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|a Wang, Yanli
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 19 vom: 23. Mai, Seite e2110690
|w (DE-627)NLM098206397
|x 1521-4095
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|g volume:34
|g year:2022
|g number:19
|g day:23
|g month:05
|g pages:e2110690
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|u http://dx.doi.org/10.1002/adma.202110690
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