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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2022.108955
|2 doi
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|a pubmed24n1122.xml
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|a (DE-627)NLM336830491
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|a (NLM)35150919
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|a (PII)S1521-6616(22)00035-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Morita, Atsushi
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Time course of peripheral immunophenotypes of multisystem inflammatory syndrome in children
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| 264 |
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1 |
|c 2022
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 16.03.2022
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|a Date Revised 21.12.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2022 Elsevier Inc. All rights reserved.
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|a The etiology of multiple inflammatory syndrome in children (MIS-C) remains poorly understood. As clues to elucidate the pathogenic condition, several characteristic peripheral immunophenotypes have been reported in MIS-C. However, no report has demonstrated the time course of the peripheral immunophenotype along with the clinical course in the same patient. Herein, we clarified the immunological characteristics of a Japanese patient with MIS-C. There was an initial cytokine storm followed by T-cell activation, especially of CD8+ T cells, with the expansion of T-cell receptor Vβ 21.3-expressing cells, which suggests superantigen-mediated T-cell activation. In addition, we also found an increase in IgG-producing cells (plasmablasts and switched memory B cells), which were accompanied by elevated serum levels of anti-SARS-CoV-2 spike antigen-specific IgG antibodies. These time course of peripheral immunophenotypes support that immunological activation against SARS-CoV-2 spike protein plays a central role in the etiology of MIS-C
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| 650 |
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|a Journal Article
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| 650 |
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|a Antibody
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| 650 |
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|a IgG
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| 650 |
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4 |
|a MIS-C
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| 650 |
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4 |
|a SARS-CoV-2
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| 650 |
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4 |
|a Spike protein
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| 650 |
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4 |
|a Vβ 21.3
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| 650 |
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7 |
|a Spike Glycoprotein, Coronavirus
|2 NLM
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| 650 |
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7 |
|a spike protein, SARS-CoV-2
|2 NLM
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| 700 |
1 |
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|a Hosaka, Sho
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Imagawa, Kazuo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ishiodori, Takumi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nozaki, Yoshihiro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Murakami, Takashi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Takada, Hidetoshi
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 236(2022) vom: 06. März, Seite 108955
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:236
|g year:2022
|g day:06
|g month:03
|g pages:108955
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4 |
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|u http://dx.doi.org/10.1016/j.clim.2022.108955
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