Time course of peripheral immunophenotypes of multisystem inflammatory syndrome in children

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 236(2022) vom: 06. März, Seite 108955
1. Verfasser:	Morita, Atsushi (VerfasserIn)
Weitere Verfasser:	Hosaka, Sho, Imagawa, Kazuo, Ishiodori, Takumi, Nozaki, Yoshihiro, Murakami, Takashi, Takada, Hidetoshi
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2022
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Antibody IgG MIS-C SARS-CoV-2 Spike protein Vβ 21.3 Spike Glycoprotein, Coronavirus spike protein, SARS-CoV-2

Beschreibung
Zusammenfassung:	Copyright © 2022 Elsevier Inc. All rights reserved. The etiology of multiple inflammatory syndrome in children (MIS-C) remains poorly understood. As clues to elucidate the pathogenic condition, several characteristic peripheral immunophenotypes have been reported in MIS-C. However, no report has demonstrated the time course of the peripheral immunophenotype along with the clinical course in the same patient. Herein, we clarified the immunological characteristics of a Japanese patient with MIS-C. There was an initial cytokine storm followed by T-cell activation, especially of CD8+ T cells, with the expansion of T-cell receptor Vβ 21.3-expressing cells, which suggests superantigen-mediated T-cell activation. In addition, we also found an increase in IgG-producing cells (plasmablasts and switched memory B cells), which were accompanied by elevated serum levels of anti-SARS-CoV-2 spike antigen-specific IgG antibodies. These time course of peripheral immunophenotypes support that immunological activation against SARS-CoV-2 spike protein plays a central role in the etiology of MIS-C
Beschreibung:	Date Completed 16.03.2022 Date Revised 21.12.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2022.108955