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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202107088
|2 doi
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|a pubmed24n1121.xml
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|a (DE-627)NLM336363311
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|a (NLM)35102632
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Xu, Bolong
|e verfasserin
|4 aut
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|a A Bioinspired Five-Coordinated Single-Atom Iron Nanozyme for Tumor Catalytic Therapy
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 15.04.2022
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|a Date Revised 15.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2022 Wiley-VCH GmbH.
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|a Single-atom nanozymes (SAzymes) represent a new research frontier in the biomedical fields. The rational design and controllable synthesis of SAzymes with well-defined electronic and geometric structures are essential for maximizing their enzyme-like catalytic activity and therapeutic efficacy but remain challenging. Here, a melamine-mediated pyrolysis activation strategy is reported for the controllable fabrication of iron-based SAzyme containing five-coordinated structure (FeN5 ), identified by transmission electron microscopy imaging and X-ray absorption fine structure analyses. The FeN5 SAzyme exhibits superior peroxidase-like activity owing to the optimized coordination structure, and the corresponding catalytic efficiency of Fe-species in the FeN5 SAzyme is 7.64 and 3.45 × 105 times higher than those in traditional FeN4 SAzyme and Fe3 O4 nanozyme, respectively, demonstrated by steady-state kinetic assay. In addition, the catalytic mechanism is jointly disclosed by experimental results and density functional theory studies. The as-synthesized FeN5 SAzyme demonstrates significantly enhanced antitumor effect in vitro and in vivo due to the excellent peroxidase-like activity under tumor microenvironment
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|a Journal Article
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|a bioinspired design
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|a peroxidase-like activity
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|a single-atom nanozymes
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|a tumor catalytic therapy
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|a Iron
|2 NLM
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| 650 |
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|a E1UOL152H7
|2 NLM
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| 650 |
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|a Peroxidase
|2 NLM
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| 650 |
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|a EC 1.11.1.7
|2 NLM
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| 700 |
1 |
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|a Li, Shanshan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Lirong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Yunhang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Han, Along
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Zhijun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Haijiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fan, Kelong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Lizeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Huiyu
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 34(2022), 15 vom: 06. Apr., Seite e2107088
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:34
|g year:2022
|g number:15
|g day:06
|g month:04
|g pages:e2107088
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202107088
|3 Volltext
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