A Bioinspired Five-Coordinated Single-Atom Iron Nanozyme for Tumor Catalytic Therapy

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 15 vom: 06. Apr., Seite e2107088
1. Verfasser:	Xu, Bolong (VerfasserIn)
Weitere Verfasser:	Li, Shanshan, Zheng, Lirong, Liu, Yunhang, Han, Along, Zhang, Jin, Huang, Zhijun, Xie, Haijiao, Fan, Kelong, Gao, Lizeng, Liu, Huiyu
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2022
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article bioinspired design peroxidase-like activity single-atom nanozymes tumor catalytic therapy Iron E1UOL152H7 Peroxidase EC 1.11.1.7

Beschreibung
Zusammenfassung:	© 2022 Wiley-VCH GmbH. Single-atom nanozymes (SAzymes) represent a new research frontier in the biomedical fields. The rational design and controllable synthesis of SAzymes with well-defined electronic and geometric structures are essential for maximizing their enzyme-like catalytic activity and therapeutic efficacy but remain challenging. Here, a melamine-mediated pyrolysis activation strategy is reported for the controllable fabrication of iron-based SAzyme containing five-coordinated structure (FeN5 ), identified by transmission electron microscopy imaging and X-ray absorption fine structure analyses. The FeN5 SAzyme exhibits superior peroxidase-like activity owing to the optimized coordination structure, and the corresponding catalytic efficiency of Fe-species in the FeN5 SAzyme is 7.64 and 3.45 × 105 times higher than those in traditional FeN4 SAzyme and Fe3 O4 nanozyme, respectively, demonstrated by steady-state kinetic assay. In addition, the catalytic mechanism is jointly disclosed by experimental results and density functional theory studies. The as-synthesized FeN5 SAzyme demonstrates significantly enhanced antitumor effect in vitro and in vivo due to the excellent peroxidase-like activity under tumor microenvironment
Beschreibung:	Date Completed 15.04.2022 Date Revised 15.04.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202107088