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231225s2022 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.1c03118
|2 doi
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|a pubmed24n1119.xml
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|a (DE-627)NLM335770606
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|a (NLM)35042338
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Sun, Shixuan
|e verfasserin
|4 aut
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|a Amino Acid-Mediated Synthesis of the ZIF-8 Nanozyme That Reproduces Both the Zinc-Coordinated Active Center and Hydrophobic Pocket of Natural Carbonic Anhydrase
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|c 2022
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 08.03.2022
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|a Date Revised 08.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The zeolitic imidazolate framework-8 (ZIF-8) nanozyme has been synthesized using hydrophobic amino acid (AA) to regulate crystal growth. The as-synthesized ZIF-8 reproduces both the structural and functional properties of natural carbonic anhydrase (CA). Structurally, Zn2+/2-methylimidazole coordinated units mimic very well the active center of CA while the hydrophobic microdomains of the adsorbed AA simulate the CA hydrophobic pocket. Functionally, the nanozymes show excellent CA-like esterase activity by giving specific enzyme activity of 0.22 U mg-1 at 25 °C in the case of Val-ZIF-8. More strikingly, such nanozymes are superior to natural CA by having excellent hydrothermal stability, which can give highly enhanced esterase activity with increasing temperature. The specific enzyme activity of Val-ZIF-8 at 80 °C is about 25 times higher than that at 25 °C. In addition, AA-ZIF-8 also shows an excellent catalytic efficiency toward carbon dioxide (CO2) hydration. This study puts forward the important role of hydrophobic microdomains in biomimetic nanozymes for the first time and develops a facile and mild method for the synthesis of nanozymes with controlled morphology and size to achieve excellent catalytic efficiency
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Amino Acids
|2 NLM
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|a Zeolites
|2 NLM
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|a 1318-02-1
|2 NLM
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|a Carbon Dioxide
|2 NLM
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|a 142M471B3J
|2 NLM
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| 650 |
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|a Carbonic Anhydrases
|2 NLM
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| 650 |
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|a EC 4.2.1.1
|2 NLM
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| 650 |
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|a Zinc
|2 NLM
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| 650 |
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|a J41CSQ7QDS
|2 NLM
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| 700 |
1 |
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|a Zhang, Zijin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xiang, Yong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cao, Meiwen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Daoyong
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 38(2022), 4 vom: 01. Feb., Seite 1621-1630
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:38
|g year:2022
|g number:4
|g day:01
|g month:02
|g pages:1621-1630
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|u http://dx.doi.org/10.1021/acs.langmuir.1c03118
|3 Volltext
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|h 1621-1630
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