Synergistic Disruption of Metabolic Homeostasis through Hyperbranched Poly(ethylene glycol) Conjugates as Nanotherapeutics to Constrain Cancer Growth

Synergistic Disruption of Metabolic Homeostasis through Hyperbranched Poly(ethylene glycol) Conjugates as Nanotherapeutics to Constrain Cancer Growth

© 2022 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 10 vom: 21. März, Seite e2109036
1. Verfasser: Pan, Dayi (VerfasserIn)
Weitere Verfasser: Zheng, Xiuli, Zhang, Lu, Li, Xin, Zhu, Guonian, Gong, Meng, Kopytynski, Michal, Zhou, Luonan, Yi, Yong, Zhu, Hongyan, Tian, Xiaohe, Chen, Rongjun, Zhang, Hu, Gu, Zhongwei, Gong, Qiyong, Luo, Kui
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2022
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article combination therapy drug delivery hyperbranched polymers multiomics self-assembly tumor metabolism Polyethylene Glycols 3WJQ0SDW1A Doxorubicin 80168379AG
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520 |a Combination therapy is a promising approach for effective treatment of tumors through synergistically regulating pathways. However, the synergistic effect is limited, likely by uncontrolled co-delivery of different therapeutic payloads in a single nanoparticle. Herein, a combination nanotherapeutic is developed by using two amphiphilic conjugates, hyperbranched poly(ethylene glycol)-pyropheophorbide-a (Ppa) (HP-P) and hyperbranched poly(ethylene glycol)-doxorubicin (DOX) (HP-D) to construct co-assembly nanoparticles (HP-PD NPs) for controllably co-loading and co-delivering Ppa and DOX. In vitro and in vivo antitumor studies confirm the synergistic effect of photodynamic therapy and chemotherapy from HP-PD NPs. Metabolic variations reveal that tumor suppression is associated with disruption of metabolic homeostasis, leading to reduced protein translation. This study uncovers the manipulation of metabolic changes in tumor cells through disruption of cellular homeostasis using HP-PD NPs and provides a new insight into the rational design of synergistic nanotherapeutics for combination therapy 
650 4 |a Journal Article 
650 4 |a combination therapy 
650 4 |a drug delivery 
650 4 |a hyperbranched polymers 
650 4 |a multiomics 
650 4 |a self-assembly 
650 4 |a tumor metabolism 
650 7 |a Polyethylene Glycols  |2 NLM 
650 7 |a 3WJQ0SDW1A  |2 NLM 
650 7 |a Doxorubicin  |2 NLM 
650 7 |a 80168379AG  |2 NLM 
700 1 |a Zheng, Xiuli  |e verfasserin  |4 aut 
700 1 |a Zhang, Lu  |e verfasserin  |4 aut 
700 1 |a Li, Xin  |e verfasserin  |4 aut 
700 1 |a Zhu, Guonian  |e verfasserin  |4 aut 
700 1 |a Gong, Meng  |e verfasserin  |4 aut 
700 1 |a Kopytynski, Michal  |e verfasserin  |4 aut 
700 1 |a Zhou, Luonan  |e verfasserin  |4 aut 
700 1 |a Yi, Yong  |e verfasserin  |4 aut 
700 1 |a Zhu, Hongyan  |e verfasserin  |4 aut 
700 1 |a Tian, Xiaohe  |e verfasserin  |4 aut 
700 1 |a Chen, Rongjun  |e verfasserin  |4 aut 
700 1 |a Zhang, Hu  |e verfasserin  |4 aut 
700 1 |a Gu, Zhongwei  |e verfasserin  |4 aut 
700 1 |a Gong, Qiyong  |e verfasserin  |4 aut 
700 1 |a Luo, Kui  |e verfasserin  |4 aut 
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773 1 8 |g volume:34  |g year:2022  |g number:10  |g day:21  |g month:03  |g pages:e2109036 
856 4 0 |u http://dx.doi.org/10.1002/adma.202109036  |3 Volltext 
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