Synergistic Disruption of Metabolic Homeostasis through Hyperbranched Poly(ethylene glycol) Conjugates as Nanotherapeutics to Constrain Cancer Growth

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 34(2022), 10 vom: 21. März, Seite e2109036
1. Verfasser:	Pan, Dayi (VerfasserIn)
Weitere Verfasser:	Zheng, Xiuli, Zhang, Lu, Li, Xin, Zhu, Guonian, Gong, Meng, Kopytynski, Michal, Zhou, Luonan, Yi, Yong, Zhu, Hongyan, Tian, Xiaohe, Chen, Rongjun, Zhang, Hu, Gu, Zhongwei, Gong, Qiyong, Luo, Kui
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2022
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article combination therapy drug delivery hyperbranched polymers multiomics self-assembly tumor metabolism Polyethylene Glycols 3WJQ0SDW1A Doxorubicin 80168379AG

Beschreibung
Zusammenfassung:	© 2022 Wiley-VCH GmbH. Combination therapy is a promising approach for effective treatment of tumors through synergistically regulating pathways. However, the synergistic effect is limited, likely by uncontrolled co-delivery of different therapeutic payloads in a single nanoparticle. Herein, a combination nanotherapeutic is developed by using two amphiphilic conjugates, hyperbranched poly(ethylene glycol)-pyropheophorbide-a (Ppa) (HP-P) and hyperbranched poly(ethylene glycol)-doxorubicin (DOX) (HP-D) to construct co-assembly nanoparticles (HP-PD NPs) for controllably co-loading and co-delivering Ppa and DOX. In vitro and in vivo antitumor studies confirm the synergistic effect of photodynamic therapy and chemotherapy from HP-PD NPs. Metabolic variations reveal that tumor suppression is associated with disruption of metabolic homeostasis, leading to reduced protein translation. This study uncovers the manipulation of metabolic changes in tumor cells through disruption of cellular homeostasis using HP-PD NPs and provides a new insight into the rational design of synergistic nanotherapeutics for combination therapy
Beschreibung:	Date Completed 31.03.2022 Date Revised 15.11.2023 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202109036