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231225s2021 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2021.108821
|2 doi
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|a pubmed24n1097.xml
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|a (DE-627)NLM329356852
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|a (NLM)34391937
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|a (PII)S1521-6616(21)00158-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Deyà-Martínez, A
|e verfasserin
|4 aut
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|a COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era
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|c 2021
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 09.09.2021
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|a Date Revised 28.03.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2021 Elsevier Inc. All rights reserved.
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|a BACKGROUND: Information regarding inborn error of immunity (IEI) as a risk factor for severe COVID-19 is scarce. We aimed to determine if paediatric patients with moderate/severe IEI got COVID-19 at the same level as the general population, and to describe COVID-19 expression
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| 520 |
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|a MATERIAL AND METHODS: We included patients with moderate/severe IEI aged 0-21 years old: cross-sectional study (June2020) to determine the prevalence of COVID-19; prospective study (January2020-January2021) including IEI patients with COVID-19. Assays used: nasopharyngeal swab SARS-CoV-2 PCR and SARS-CoV-2-specific immunoglobulins
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|a RESULTS: Seven from sixty-five patients tested positive (prevalence: 10.7% (7%-13%)) after the first SARS-COV-2 wave and 13/15 patients diagnosed with COVID-19 had an asymptomatic/mild course
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|a CONCLUSIONS: In our area, prevalence of COVID-19 in moderate/severe IEI paediatric patients after the first wave was slightly higher than in the general population. The majority of patients presented a benign course, suggesting a possible protective factor related with age despite IEI
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|a Journal Article
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|a Children, COVID-19
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| 650 |
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|a Inborn errors immunity
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| 650 |
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|a Primary immunodeficiency disease
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1 |
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|a García-García, A
|e verfasserin
|4 aut
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| 700 |
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|a Gonzalez-Navarro, E A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yiyi, L
|e verfasserin
|4 aut
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| 700 |
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|a Vlagea, A
|e verfasserin
|4 aut
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| 700 |
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|a Jordan, I
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fumadó, V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fortuny, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Español, M
|e verfasserin
|4 aut
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| 700 |
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|a Launes, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Esteve-Solé, A
|e verfasserin
|4 aut
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| 700 |
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|a Juan, M
|e verfasserin
|4 aut
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|a Pascal, M
|e verfasserin
|4 aut
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| 700 |
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|a Alsina, L
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 230(2021) vom: 30. Sept., Seite 108821
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:230
|g year:2021
|g day:30
|g month:09
|g pages:108821
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2021.108821
|3 Volltext
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