Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ß-Elemene for Cancer Therapy

Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ß-Elemene for Cancer Therapy

© 2021 Wiley-VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 33(2021), 37 vom: 15. Sept., Seite e2102054
1. Verfasser: Liu, Chuang (VerfasserIn)
Weitere Verfasser: Sun, Shan, Feng, Qiang, Wu, Gongwei, Wu, Yiting, Kong, Na, Yu, Zhangsen, Yao, Junlie, Zhang, Xingcai, Chen, Wei, Tang, Zhongmin, Xiao, Yufen, Huang, Xiangang, Lv, Aman, Yao, Chenyang, Cheng, Haibo, Wu, Aiguo, Xie, Tian, Tao, Wei
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2021
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article 2D materials arsenene nanodots combination cancer therapy selective killing effects ß-elemene Antineoplastic Agents Reactive Oxygen Species Sesquiterpenes beta-elemene mehr... Polyethylene Glycols 3WJQ0SDW1A Arsenic N712M78A8G
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520 |a Arsenical drugs have achieved hallmark success in treating patients with acute promyelocytic leukemia, but expanding their clinical utility to solid tumors has proven difficult with the contradiction between the therapeutic efficacy and the systemic toxicity. Here, leveraging efforts from materials science, biocompatible PEGylated arsenene nanodots (AsNDsPEG) with high monoelemental arsenic purity that can selectively and effectively treat solid tumors are synthesized. The intrinsic selective killing effect of AsNDs@PEG is closely related to high oxidative stress in tumor cells, which leads to an activated valence-change of arsenic (from less toxic As0 to severely toxic oxidation states), followed by decreased superoxide dismutase activity and massive reactive oxygen species (ROS) production. These effects occur selectively within cancer cells, causing mitochondrial damage, cell-cycle arrest, and DNA damage. Moreover, AsNDs@PEG when applied in a multi-drug combination strategy with β-elemene, a plant-derived anticancer drug, achieves synergistic antitumor outcomes, and its newly discovered on-demand photothermal properties facilitate the elimination of the tumors without recurrence, potentially further expanding its clinical utility. In line of the practicability for a large-scale fabrication and negligible systemic toxicity of AsNDs@PEG (even at high doses and with repetitive administration), a new-concept arsenical drug with high therapeutic efficacy for selective solid tumor therapy is provided 
650 4 |a Journal Article 
650 4 |a 2D materials 
650 4 |a arsenene nanodots 
650 4 |a combination cancer therapy 
650 4 |a selective killing effects 
650 4 |a ß-elemene 
650 7 |a Antineoplastic Agents  |2 NLM 
650 7 |a Reactive Oxygen Species  |2 NLM 
650 7 |a Sesquiterpenes  |2 NLM 
650 7 |a beta-elemene  |2 NLM 
650 7 |a Polyethylene Glycols  |2 NLM 
650 7 |a 3WJQ0SDW1A  |2 NLM 
650 7 |a Arsenic  |2 NLM 
650 7 |a N712M78A8G  |2 NLM 
700 1 |a Sun, Shan  |e verfasserin  |4 aut 
700 1 |a Feng, Qiang  |e verfasserin  |4 aut 
700 1 |a Wu, Gongwei  |e verfasserin  |4 aut 
700 1 |a Wu, Yiting  |e verfasserin  |4 aut 
700 1 |a Kong, Na  |e verfasserin  |4 aut 
700 1 |a Yu, Zhangsen  |e verfasserin  |4 aut 
700 1 |a Yao, Junlie  |e verfasserin  |4 aut 
700 1 |a Zhang, Xingcai  |e verfasserin  |4 aut 
700 1 |a Chen, Wei  |e verfasserin  |4 aut 
700 1 |a Tang, Zhongmin  |e verfasserin  |4 aut 
700 1 |a Xiao, Yufen  |e verfasserin  |4 aut 
700 1 |a Huang, Xiangang  |e verfasserin  |4 aut 
700 1 |a Lv, Aman  |e verfasserin  |4 aut 
700 1 |a Yao, Chenyang  |e verfasserin  |4 aut 
700 1 |a Cheng, Haibo  |e verfasserin  |4 aut 
700 1 |a Wu, Aiguo  |e verfasserin  |4 aut 
700 1 |a Xie, Tian  |e verfasserin  |4 aut 
700 1 |a Tao, Wei  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 33(2021), 37 vom: 15. Sept., Seite e2102054  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:33  |g year:2021  |g number:37  |g day:15  |g month:09  |g pages:e2102054 
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