Arsenene Nanodots with Selective Killing Effects and their Low-Dose Combination with ß-Elemene for Cancer Therapy

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 33(2021), 37 vom: 15. Sept., Seite e2102054
1. Verfasser:	Liu, Chuang (VerfasserIn)
Weitere Verfasser:	Sun, Shan, Feng, Qiang, Wu, Gongwei, Wu, Yiting, Kong, Na, Yu, Zhangsen, Yao, Junlie, Zhang, Xingcai, Chen, Wei, Tang, Zhongmin, Xiao, Yufen, Huang, Xiangang, Lv, Aman, Yao, Chenyang, Cheng, Haibo, Wu, Aiguo, Xie, Tian, Tao, Wei
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2021
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article 2D materials arsenene nanodots combination cancer therapy selective killing effects ß-elemene Antineoplastic Agents Reactive Oxygen Species Sesquiterpenes beta-elemene mehr... Polyethylene Glycols 3WJQ0SDW1A Arsenic N712M78A8G

Beschreibung
Zusammenfassung:	© 2021 Wiley-VCH GmbH. Arsenical drugs have achieved hallmark success in treating patients with acute promyelocytic leukemia, but expanding their clinical utility to solid tumors has proven difficult with the contradiction between the therapeutic efficacy and the systemic toxicity. Here, leveraging efforts from materials science, biocompatible PEGylated arsenene nanodots (AsNDsPEG) with high monoelemental arsenic purity that can selectively and effectively treat solid tumors are synthesized. The intrinsic selective killing effect of AsNDs@PEG is closely related to high oxidative stress in tumor cells, which leads to an activated valence-change of arsenic (from less toxic As0 to severely toxic oxidation states), followed by decreased superoxide dismutase activity and massive reactive oxygen species (ROS) production. These effects occur selectively within cancer cells, causing mitochondrial damage, cell-cycle arrest, and DNA damage. Moreover, AsNDs@PEG when applied in a multi-drug combination strategy with β-elemene, a plant-derived anticancer drug, achieves synergistic antitumor outcomes, and its newly discovered on-demand photothermal properties facilitate the elimination of the tumors without recurrence, potentially further expanding its clinical utility. In line of the practicability for a large-scale fabrication and negligible systemic toxicity of AsNDs@PEG (even at high doses and with repetitive administration), a new-concept arsenical drug with high therapeutic efficacy for selective solid tumor therapy is provided
Beschreibung:	Date Completed 25.01.2022 Date Revised 25.01.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202102054